Monaco S, Lucci B, Laperchia N, Tezzon F, Currò-Dossi B, Nardelli E, Giannini C, Rizzuto N
Cattedra di Neuropatologia, Verona, Italy.
Neurology. 1988 Mar;38(3):494-6. doi: 10.1212/wnl.38.3.494.
We investigated two patients with the idiopathic hypereosinophilic syndrome and peripheral neuropathy. Clinical, EMG, and pathological findings were consistent with axonal polyneuropathy. Morphologic changes of the nerve biopsies suggested axonal damage secondary to increased endoneurial pressure from leakage of capillaries. We postulate that endothelial cell damage, followed by nerve edema, is the first step in the pathogenesis of peripheral neuropathy in these patients.
我们研究了两名患有特发性嗜酸性粒细胞增多综合征和周围神经病变的患者。临床、肌电图及病理检查结果均符合轴索性多发性神经病。神经活检的形态学改变提示，毛细血管渗漏导致神经内膜压力升高继发轴索损伤。我们推测，内皮细胞损伤继而引发神经水肿，是这些患者周围神经病变发病机制的第一步。
