Rossant Janet
Program in Developmental and Stem Cell Biology, Hospital for Sick Children, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario, Canada M5G OA4 Department of Molecular Genetics, University of Toronto, Peter Gilgan Centre for Research and Learning, 686 Bay Street, Toronto, Ontario, Canada M5G OA4
Development. 2015 Jan 1;142(1):9-12. doi: 10.1242/dev.115451.
Lessons learned from conserved vertebrate developmental pathways have catalyzed rapid advances in pluripotent stem cell differentiation towards therapeutically relevant cell types. The most highly conserved phases of development are associated with the early patterning of the body plan - the so-called phylotypic stage. Both prior to and after this stage there is much more divergence across species. Developmental differences between human and mouse at the blastocyst and early post-implantation stages might help explain the differences among the different stem cell lines derived from these embryos. A better understanding of these early stages of human development will aid our ability to generate and manipulate human stem cells and their derivatives.
从保守的脊椎动物发育途径中汲取的经验教训，推动了多能干细胞向具有治疗意义的细胞类型分化方面的快速进展。发育过程中最高度保守的阶段与身体蓝图的早期模式形成相关，即所谓的系统发育阶段。在这个阶段之前和之后，物种间的差异要大得多。人类和小鼠在囊胚期及植入后早期的发育差异，可能有助于解释源自这些胚胎的不同干细胞系之间的差异。更好地了解人类发育的这些早期阶段，将有助于我们生成和操控人类干细胞及其衍生物的能力。
