Wu Fangqin, He Mei'an, Wen Qiang, Zhang Wencai, Yang Jinhua, Zhang Xiaomin, Wu Tangchun, Cheng Longxian
Department of Cardiology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Dadao, Wuhan 430022, China.
Institute of Occupational Medicine and the Ministry of Education, Key Lab of Environment and Health, School of Public Health, Tongji Medical College, Huazhong University of Science and Technology, 13 HangKong Road, Wuhan 430030, China.
Int J Mol Sci. 2014 Dec 15;15(12):23227-39. doi: 10.3390/ijms151223227.
The IL-33/ST2 signaling pathway plays an important role in coronary artery disease (CHD); however, few studies have explored how variants in IL-33/ST2 genes influence CHD risk. Here, we examined the association between genetic variants in IL-33, ST2, and IL-1RAcP of the IL-33/ST2 axis and the risk of CHD. We conducted a case-controlled study with 1146 CHD cases and 1146 age- and sex-frequency-matched controls. Twenty-eight single nucleotide polymorphisms (SNPs) in IL-33, ST2, and IL-1RAcP were genotyped by Sequenom MassArray and TaqMan assay. Logistic regression was used to analyze these associations. The SNP rs4624606 in IL-1RAcP was nominally associated with CHD risk. The AA genotype was associated with a 1.85-fold increased risk of CHD (95% confidence interval (CI) = 1.01-3.36; p = 0.045) compared to the TT genotype. Further analysis showed that AA carriers also had a higher risk of CHD than TT + TA carriers (odds ratio (OR) = 1.85; 95% CI = 1.85-3.35; p = 0.043). However, no significant association was observed between variants in IL-33/ST2 genes and CHD risk. Further studies are needed to replicate our results in other ethnic groups with larger sample size.
白细胞介素-33/ST2信号通路在冠状动脉疾病（CHD）中起重要作用；然而，很少有研究探讨白细胞介素-33/ST2基因变异如何影响冠心病风险。在此，我们研究了白细胞介素-33/ST2轴的白细胞介素-33、ST2和白细胞介素-1受体拮抗剂（IL-1RAcP）基因变异与冠心病风险之间的关联。我们进行了一项病例对照研究，纳入1146例冠心病患者和1146例年龄和性别频率匹配的对照。通过Sequenom MassArray和TaqMan分析对白细胞介素-33、ST2和IL-1RAcP中的28个单核苷酸多态性（SNP）进行基因分型。采用逻辑回归分析这些关联。IL-1RAcP中的SNP rs4624606与冠心病风险存在名义上的关联。与TT基因型相比，AA基因型与冠心病风险增加1.85倍相关（95%置信区间（CI）=1.01-3.36；p = 0.045）。进一步分析表明，AA携带者患冠心病的风险也高于TT + TA携带者（优势比（OR）=1.85；95%CI = 1.85-3.35；p = 0.043）。然而，未观察到白细胞介素-33/ST2基因变异与冠心病风险之间存在显著关联。需要进一步研究以在其他种族的更大样本中重复我们的结果。
