吸烟作为慢性肾脏病的危险因素：系统评价
Smoking as risk factor for chronic kidney disease: systematic review.
作者信息
Elihimas Júnior Ubiracé Fernando, Elihimas Helen Conceição dos Santos, Lemos Victor Macedo, Leão Mariana de Albuquerque, Sá Michel Pompeu Barros de Oliveira, França Eduardo Eriko Tenório de, Lemos Andrea, Valente Lucila Maria, Markman Filho Brivaldo
机构信息
Universidade Federal de Pernambuco.
Universidade de Pernambuco.
出版信息
J Bras Nefrol. 2014 Oct-Dec;36(4):519-28. doi: 10.5935/0101-2800.20140074.
INTRODUCTION
Chronic kidney disease (CKD) and smoking are public health problems.
OBJECTIVE
To assess smoking as a risk factor for progression of CKD.
METHODS
We conducted a systematic review in Medline, LILACS, SciELO, Google Scholar, Embase and Trials.gov with articles published until February/2013. Were included: cohort, clinical trials and case-control. Performed in humans, aged ≥ 18 years with smoking as a risk factor for progression of CKD. We excluded studies that reported no smoking and CKD in the title or had proposed to reduce smoking.
RESULTS
Among 94 citations, 12 articles were selected. Of these, six were multicenter conducted in developed countries, four were randomized. Males predominated 51-76%. There was associated with smoking progression in 11 studies. It was found that the consumption ≥ 15 packs/ year increases the risk of progression of CKD.
CONCLUSION
Smoking is a risk factor for progression of CKD.
引言
慢性肾脏病（CKD）和吸烟是公共卫生问题。
目的
评估吸烟作为CKD进展的危险因素。
方法
我们在Medline、LILACS、SciELO、谷歌学术、Embase和Trials.gov上进行了一项系统综述，纳入截至2013年2月发表的文章。纳入的研究类型包括队列研究、临床试验和病例对照研究。研究对象为年龄≥18岁的人群，吸烟作为CKD进展的危险因素。我们排除了标题中未提及吸烟与CKD或旨在减少吸烟的研究。
结果
在94篇被引文献中，筛选出12篇文章。其中，6篇是在发达国家进行的多中心研究，4篇是随机对照研究。男性占比51%-76%。11项研究发现吸烟与疾病进展相关。研究发现，每年吸烟量≥15包会增加CKD进展的风险。
结论
吸烟是CKD进展的危险因素。
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