Verona University Hospital and Department of Pathology and Diagnostics, University of Verona, 37134 Verona, Italy.
Immunity. 2014 Nov 20;41(5):679-81. doi: 10.1016/j.immuni.2014.11.004.
Immunotherapy is revolutionizing the treatment of cancer patients, but the molecular basis for tumor immunogenicity is unclear. In this issue of Immunity, Deng et al. (2014) and Woo et al. (2014) provide evidence suggesting that dendritic cells detect DNA from tumor cells via the STING-mediated, cytosolic DNA sensing pathway.
免疫疗法正在彻底改变癌症患者的治疗方式，但肿瘤免疫原性的分子基础尚不清楚。在本期《免疫》杂志中，Deng 等人（2014 年）和 Woo 等人（2014 年）提供的证据表明，树突状细胞通过 STING 介导的细胞质 DNA 感应途径检测来自肿瘤细胞的 DNA。
