在抗肿瘤免疫监视中产生白细胞介素-12 的 CD103+树突状细胞。
CD103+ dendritic cells producing interleukin-12 in anticancer immunosurveillance.
机构信息
Gustave Roussy Cancer Campus, 94805 Villejuif, France; INSERM U1015, 94805 Villejuif, France; Université Paris Sud-XI, Faculté de Médecine, Le Kremlin Bicêtre, 91400 Orsay, France; Center of Clinical Investigations in Biotherapies of Cancer (CICBT) 507, 94805 Villejuif, France.
Gustave Roussy Cancer Campus, 94805 Villejuif, France; Université Paris Descartes, Sorbonne Paris Cité, 75006 Paris, France; Metabolomics and Cell Biology Platforms, Gustave Roussy, 94805 Villejuif, France; Equipe 11 labellisée Ligue contre le Cancer, Centre de Recherche des Cordeliers, INSERM U 1138, 75006 Paris, France; Pôle de Biologie, Hôpital Européen Georges Pompidou, AP-HP, 75006 Paris, France.
出版信息
Cancer Cell. 2014 Nov 10;26(5):591-3. doi: 10.1016/j.ccell.2014.10.008.
The mechanisms through which tumor antigen-specific T cells are elicited in natural or chemotherapy-induced immunosurveillance have been elusive. In this issue of Cancer Cell, two papers by Broz and colleagues and Ruffell and colleagues delineate an important role for a specific dendritic cell subset characterized by CD103 expression, dependence on transcription factors Batf3 and Irf8, and interleukin-12 production.
肿瘤抗原特异性 T 细胞在自然或化疗诱导的免疫监视中被激活的机制一直难以捉摸。在本期《癌细胞》杂志上，Broz 及其同事以及 Ruffell 及其同事的两篇论文描绘了一个具有特殊作用的树突状细胞亚群，其特征是表达 CD103、依赖转录因子 Batf3 和 Irf8 以及产生白细胞介素-12。
Zotero 插件