通过破坏来构建：癌症新染色体的发展。

Building through breaking: the development of cancer neochromosomes.

机构信息

Genetics Branch, Center for Cancer Research, National Cancer Institute, 37 Convent Drive, Bethesda, MD 20892, USA.

出版信息

Cancer Cell. 2014 Nov 10;26(5):593-5. doi: 10.1016/j.ccell.2014.10.013.

DOI:10.1016/j.ccell.2014.10.013

Abstract

In this issue of Cancer Cell, Garsed and colleagues combine chromosome flow sorting and deep sequencing to characterize the structure of oncogene-containing neochromosomes in liposarcoma and provide evidence that they are generated by a combination of multiple dynamic and destructive processes.

摘要

在本期《癌细胞》中，Garsed 及其同事将染色体流式分选与深度测序相结合，对脂肪肉瘤中含癌基因的新染色体结构进行了特征描述，并提供了证据表明它们是由多种动态和破坏性过程共同作用产生的。