IRCCS Santa Lucia Foundation, Department of Biology, University of Tor Vergata, 00173 Rome, Italy; Unit of Cell Stress and Survival, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Unit of Cell Death and Metabolism, Danish Cancer Society Research Center, 2100 Copenhagen, Denmark.
Cancer Cell. 2014 Nov 10;26(5):599-600. doi: 10.1016/j.ccell.2014.10.014.
Autophagy is an important cellular homeostasis pathway, but its role in cancer remains to be fully elucidated. In this issue of Cancer Cell, Hall and colleagues describe a TRPM3-dependent autophagy pathway that is selectively important for clear cell renal cell carcinoma and can be effectively inhibited.
自噬是一种重要的细胞内稳态途径，但它在癌症中的作用仍有待充分阐明。在本期《癌细胞》杂志中，Hall 及其同事描述了一个依赖于 TRPM3 的自噬途径，该途径对透明细胞肾细胞癌具有选择性重要性，并且可以被有效抑制。
