Doz François
Bull Acad Natl Med. 2013 Apr-May;197(4-5):865-76; discussion 876.
Numerous cytotoxic drugs used to treat childhood cancers, as well as pelvic or hypothalamo- pituitary irradiation and gonadal surgery, can affect subsequent hormonal function and fertility. Prevention of these adverse consequences is based primarily on therapeutic de-escalation when possible, and now also on gonad or gamete preservation. These patients and their parents must receive thorough information, taking into account the child's age, the proposed treatments, and the length of follow-up. Teams treating childhood cancers must receive appropriate training, and access to innovative fertility-preserving techniques must be guaranteed at the national level.
许多用于治疗儿童癌症的细胞毒性药物，以及盆腔或下丘脑 - 垂体放疗和性腺手术，都可能影响后续的激素功能和生育能力。预防这些不良后果主要基于尽可能进行治疗降级，现在还基于性腺或配子保存。必须根据儿童的年龄、拟采用的治疗方法和随访时间，向这些患者及其父母提供全面信息。治疗儿童癌症的团队必须接受适当培训，并且必须在国家层面确保获得创新的生育力保存技术。
