Dittrich R, Maltaris T, Hoffmann I, Oppelt P G, Beckmann M W, Mueller A
Department of Obstetrics and Gynecology, Erlangen University Hospital, University of Erlangen-Nuremberg, Erlangen, Germany.
Minerva Ginecol. 2010 Feb;62(1):63-80.
Today the vast majority of children and adolescents diagnosed with cancer achieve relatively high rates of remission and long-term survival, due to significant advances in oncological treatment. Oncological surgery, radiotherapy and chemotherapy however, are often detrimental to fertility, thus substantially impacting a patient's quality of life. Concerns about fertility are similar for men and women; however, their opportunities for intervention differ considerably. This article reviews the literature, discusses the etiology and effects of cancer treatment on fertility, and presents the current and emerging options for the preservation of fertility in patients with cancer. The various diagnostic methods of assessing the fertility potential at the time of diagnosis and the efficacy of the different fertility preserving methods after cancer treatment are also presented.
如今，由于肿瘤治疗取得了重大进展，绝大多数被诊断患有癌症的儿童和青少年实现了相对较高的缓解率和长期生存率。然而，肿瘤外科手术、放疗和化疗通常会对生育能力造成损害，从而对患者的生活质量产生重大影响。男性和女性对生育问题的担忧相似；然而，他们的干预机会却有很大差异。本文回顾了相关文献，讨论了癌症治疗对生育能力的病因及影响，并介绍了目前和新出现的癌症患者生育力保存方法。还介绍了在诊断时评估生育潜力的各种诊断方法以及癌症治疗后不同生育力保存方法的疗效。
