Boonya-ussadorn Trirat, Choi Woo Hee, Hyun Joo, Kim Sung Hoon, Chung Soo Kyo, Yoo Ie Ryung
J Med Assoc Thai. 2014 Feb;97 Suppl 2:S115-22.
To study 18F-FDG PET/CT findings in endometrial cancer patients, to analyze the correlation between the maximum standardized uptake value (SUVmax) and clinicopathologic tumor characteristics.
Retrospective study included 33 endometrial cancer patients who underwent pre-operative 18F-FDG PET/CT and abdominal CT or MRI from June 2005 to October 2009. Pattern of FDG uptake was classified as focal and diffuse uptake. SUVmax was measured at primary tumor in endometrial cavity and correlated with maximum tumor size, menopausal state, histological grade, depth of myometrial invasion and nodal metastasis. The diagnostic performance of 18F-FDG PET/CT was assessed for primary tumor and lymph node metastasis and correlated with those of CT/MRI.
Sensitivity of 18F-FDG PET/CT in primary tumor detection was slightly higher, without significant difference, than that of either CT or MRI (93.9% vs. 87.9%, p = 0.625). The overall SUVmax mean ofthe primary tumor was 8.24 +/- 5.38. The focal FDG uptake pattern was more common than the diffuse uptake pattern (71.0% and 29.0%, respectively), but the SUVmax was higher in the diffuse uptake pattern (diffuse pattern 12.10 +/- 7.47 vs. focal pattern 6.66 +/- 3.33, p = 0.008). There was significant association between the SUVmax of the primary tumor and maximum tumor size (p = 0.001), but not between the SUVmax of the primary tumor and menopause state, histological grade, depth of myometrial invasion and nodal metastasis (p = 0.522, 0.622, 0.694 and 0.601, respectively). For lymph node detection, the sensitivity of 18F-FDG PET/CT were also higher without statistically significant difference, than those of CT/MRI (on patient basis; 80.0% vs. 40.0%, p = 0.500; on nodal basis 64.7% vs. 47.1%, p = 0.453, respectively).
18F-FDG PET/CThad slightly higher diagnostic sensitivity than CT/MRIin both primary tumor and lymph node detection. The finding focal uptake pattern is more common, but the diffuse uptake pattern shows higher FDG uptake. The SUVmax of primary tumors was associated with the maximum tumor size, but not associated with menopause state, histologic grade, depth of myometrial invasion and nodal metastasis.
研究子宫内膜癌患者的18F-FDG PET/CT表现，分析最大标准化摄取值（SUVmax）与临床病理肿瘤特征之间的相关性。
回顾性研究纳入了2005年6月至2009年10月期间接受术前18F-FDG PET/CT及腹部CT或MRI检查的33例子宫内膜癌患者。FDG摄取模式分为局灶性摄取和弥漫性摄取。在子宫内膜腔内的原发肿瘤处测量SUVmax，并将其与最大肿瘤大小、绝经状态、组织学分级、肌层浸润深度及淋巴结转移情况进行相关性分析。评估18F-FDG PET/CT对原发肿瘤及淋巴结转移的诊断性能，并与CT/MRI的诊断性能进行相关性分析。
18F-FDG PET/CT对原发肿瘤检测的敏感性略高于CT或MRI，但无显著差异（93.9%对87.9%，p = 0.625）。原发肿瘤的总体SUVmax平均值为8.24±5.38。局灶性FDG摄取模式比弥漫性摄取模式更常见（分别为71.0%和29.0%），但弥漫性摄取模式的SUVmax更高（弥漫性模式为12.10±7.47，局灶性模式为6.66±3.33，p = 0.008）。原发肿瘤的SUVmax与最大肿瘤大小之间存在显著相关性（p = 0.001），但与绝经状态、组织学分级、肌层浸润深度及淋巴结转移之间无相关性（p分别为0.522、0.622、0.694和0.601）。对于淋巴结检测，18F-FDG PET/CT的敏感性也高于CT/MRI，但无统计学显著差异（基于患者；80.0%对40.0%，p = 0.500；基于淋巴结；64.7%对47.1%，p = 0.453）。
18F-FDG PET/CT在原发肿瘤和淋巴结检测方面的诊断敏感性略高于CT/MRI。局灶性摄取模式更常见，但弥漫性摄取模式显示出更高的FDG摄取。原发肿瘤的SUVmax与最大肿瘤大小相关，但与绝经状态、组织学分级、肌层浸润深度及淋巴结转移无关。
