Sakamoto Shinichi, Ichikawa Tomohiko
Nihon Rinsho. 2014 Dec;72(12):2086-9.
Prostate cancer cells pass through numerous steps during the process of progression and metastasis. Cancer cells from primary site undertake "epithelial-mesenchymal transition (EMT)" and migrate into neighboring site and invade into blood vessels. Migrated cancer cells will detach from extracellular matrix (ECM) and float into distant metastasis site. Those detached cells will go through either "apoptosis" or acquire "anoikis resistance" and, finally, transfer to distant metastasis site. When settle at novel metastasis site, "mesenchymal-epithelial transition (MET)" will take place. Receptor activator of nuclear factor κ-B ligand (RANKL) plays significant role in formation of bone metastasis site.
前列腺癌细胞在进展和转移过程中会经历多个步骤。来自原发部位的癌细胞进行“上皮-间质转化（EMT）”，迁移到邻近部位并侵入血管。迁移的癌细胞会从细胞外基质（ECM）脱离，漂浮到远处转移部位。那些脱离的细胞会经历“凋亡”或获得“失巢凋亡抗性”，最终转移到远处转移部位。当在新的转移部位定居时，会发生“间质-上皮转化（MET）”。核因子κ-B受体活化因子配体（RANKL）在骨转移部位的形成中起重要作用。
