Kamoto Toshiyuki
Nihon Rinsho. 2014 Dec;72(12):2103-7.
When considering the diagnosis of castration resistant prostate cancer (CRPC), one of the possible approaches consists of performing examination and diagnosis to determine the presence of CRPC. The definition of CRPC is simple-disease progression despite a serum testosterone value below 50 ng/dL after androgen deprivation therapy (ADT). It is similar to an earlier definition--"an initial relapse" occurring after primary ADT. Therefore, it is important to determine the histopathological type of CRPC to establish a course of treatment thereafter. Regarding the "examinations" and "diagnosis" for the staging of CRPC, it is likely that the circulating tumor cell assay and quantitative imaging examinations will be needed, instead of bone scintigraphy, in the future.
在考虑去势抵抗性前列腺癌（CRPC）的诊断时，一种可能的方法是进行检查和诊断以确定CRPC的存在。CRPC的定义很简单，即尽管在雄激素剥夺治疗（ADT）后血清睾酮值低于50 ng/dL，但疾病仍进展。它类似于早期的定义——原发性ADT后出现的“首次复发”。因此，确定CRPC的组织病理学类型对于随后制定治疗方案很重要。关于CRPC分期的“检查”和“诊断”，未来可能需要循环肿瘤细胞检测和定量成像检查，而不是骨闪烁显像。
