Shimizu Fumitaka, Kanda Takashi
Nihon Rinsho. 2014 Nov;72(11):1949-54.
Pathological destruction of the blood-brain barrier(BBB) has been considered to be the initial key step of disease process in multiple sclerosis (MS) and neuromyelitis optica (NMO). The pathological findings using autopsy brain section from patients with secondary progressive (SP) MS or relapsing MS demonstrated a leaky BBB in active lesions and our recent data also showed that the sera from patients with relapsing MS or SPMS can induce the BBB breakdown. Recently, the disease-specific autoantibody "anti-aquaporin 4(AQP4) antibodies" was detected in the sera of NMO patients. Because the circulating anti-AQP4 antibodies need to pass through BBB in order to reach the astrocytic endfeets, where AQP4 localized, our recent studies demonstrated the detailed molecular mechanism of the BBB disruption in NMO.
血脑屏障（BBB）的病理破坏被认为是多发性硬化症（MS）和视神经脊髓炎（NMO）疾病进程的初始关键步骤。使用继发进展型（SP）MS或复发型MS患者的尸检脑切片进行的病理研究表明，活跃病灶中的血脑屏障存在渗漏，并且我们最近的数据还显示，复发型MS或SPMS患者的血清可诱导血脑屏障破坏。最近，在NMO患者的血清中检测到了疾病特异性自身抗体“抗水通道蛋白4（AQP4）抗体”。由于循环中的抗AQP4抗体需要穿过血脑屏障才能到达AQP4所在的星形胶质细胞终足，因此我们最近的研究揭示了NMO中血脑屏障破坏的详细分子机制。
