幽门螺杆菌感染、痴呆与原发性开角型青光眼：它们有关联吗？
Helicobacter pylori infection, dementia and primary open-angle glaucoma: are they connected?
作者信息
Tsolaki Fani, Kountouras Jannis, Topouzis Fotios, Tsolaki Magda
机构信息
Ophthalmology Department, Hippokrateion General Hospital, Thessaloniki, Greece.
Second Medical Department, Hippokrateion General Hospital, Aristotle University of Thessaloniki, Thessaloniki, Greece.
出版信息
BMC Ophthalmol. 2015 Mar 11;15:24. doi: 10.1186/s12886-015-0006-2.
Abstract
BACKGROUND
The study aims to elucidate the putative association between various forms of dementia, including Alzheimer's disease, primary open-angle glaucoma and Helicobacter pylori (H.pylori) infection in all possible combinations.
METHODS
We prospectively recruited for the study 156 patients, divided into a dementia group, a glaucoma group and two control groups. All patients were submitted to neuropsychological evaluation aiming to detect dementia, ophthalmological examination, aiming to detect glaucoma, and H.pylori diagnostic testing. The provided data were analyzed with the question of possible correlation between the aforementioned entities.
RESULTS
Positive correlations were found between Hp infection and dementia, Hp infection and glaucoma, as well as between dementia and glaucoma.
CONCLUSIONS
The study confirmed the hypothesis that neurodegenerative diseases such as dementia and glaucoma are linked to each other and to H.pylori infection.
摘要
背景
本研究旨在阐明各种形式的痴呆症（包括阿尔茨海默病）、原发性开角型青光眼与幽门螺杆菌（H.pylori）感染之间所有可能组合的假定关联。
方法
我们前瞻性地招募了156名患者，分为痴呆症组、青光眼组和两个对照组。所有患者均接受旨在检测痴呆症的神经心理学评估、旨在检测青光眼的眼科检查以及幽门螺杆菌诊断测试。对提供的数据进行分析，以探讨上述各实体之间可能的相关性问题。
结果
发现幽门螺杆菌感染与痴呆症、幽门螺杆菌感染与青光眼以及痴呆症与青光眼之间存在正相关。
结论
该研究证实了如下假设，即痴呆症和青光眼等神经退行性疾病彼此相关且与幽门螺杆菌感染有关。
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