Takeda Akitoshi
Nihon Rinsho. 2014 Nov;72(11):1989-94.
The prevalence of cognitive impairment is about 40-65% in patients with multiple sclerosis (MS). Cognitive decline appears in MS in the early stages of the disease including clinically isolated syndrome and radiologically isolated syndrome. Cognitive impairments in patients with MS influence their social functioning and employment. Various domains of cognitive function, including processing speed/working memory, long-term memory, word retrieval, visuospatial processing, and executive function are affected in patients with MS. The Brief Repeatable Battery of Neuropsychological Tests (BRB-N) in MS and the Minimal Assessment of Cognitive Function in MS (MACFIMS) are commonly utilized to assess cognitive function in patients with MS. Neuropsychological assessments are important in MS to predict prognosis and cognitive outcome in treatment trials.
在多发性硬化症（MS）患者中，认知障碍的患病率约为40%-65%。认知功能衰退在MS疾病的早期阶段就会出现，包括临床孤立综合征和放射学孤立综合征。MS患者的认知障碍会影响其社交功能和就业。MS患者的各种认知功能领域，包括处理速度/工作记忆、长期记忆、词汇检索、视觉空间处理和执行功能都会受到影响。MS中的简短可重复神经心理测试组（BRB-N）和MS认知功能最小评估（MACFIMS）通常用于评估MS患者的认知功能。神经心理评估在MS中对于预测治疗试验的预后和认知结果很重要。
