通过双示踪剂研究确定溶酶体在67Ga肿瘤蓄积中的作用。

Determination of the lysosomal role in tumor accumulation of 67Ga by dual-tracer studies.

作者信息

Ando A, Ando I, Hiraki T, Yamada N, Hisada K

机构信息

School of Allied Medical Professions, Kanazawa University, Japan.

出版信息

Int J Rad Appl Instrum A. 1989;40(6):521-4. doi: 10.1016/0883-2889(89)90138-x.

DOI:10.1016/0883-2889(89)90138-x

PMID:2551848

Abstract

The lysosomal role in tumor accumulation of 67Ga was determined by dual-tracer (67Ga and 46Sc) studies. It became clear that 67Ga essentially did not accumulate in the tumor lysosome, and that the lysosome did not play a major role in tumor accumulation of 67Ga. In addition, it was revealed that tumor lysosome was hardly disrupted at all in some phases of fractionation procedures.

摘要

通过双示踪剂（67Ga和46Sc）研究确定了溶酶体在67Ga肿瘤蓄积中的作用。结果表明，67Ga基本上不会在肿瘤溶酶体中蓄积，且溶酶体在67Ga的肿瘤蓄积中不发挥主要作用。此外，研究还发现，在分级分离程序的某些阶段，肿瘤溶酶体几乎完全没有被破坏。