46Sc和51Cr在荷瘤动物体内的分布及其在肿瘤和肝脏中蓄积的机制。

Distribution of 46Sc and 51Cr in tumor-bearing animals and the mechanism for accumulation in tumor and liver.

作者信息

Ando A, Ando I, Yamada N, Hiraki T, Hisada K

出版信息

Int J Rad Appl Instrum B. 1987;14(2):143-51. doi: 10.1016/0883-2897(87)90145-0.

Abstract

Tumor uptake rates, concentrations in mitochondrial fraction (containing lysosome) of liver and tumors, avid accumulations in connective tissue (especially inflammatory tissue) and binding substances in these tissues for 46Sc3+ and 51Cr3+ were essentially similar to those for 67Ga3+, 111In3+, 169Yb3+, 167Tm3+, 95Zr4+ and 181Hf4+. However, the main binding substance of 46Sc3+ and 51Cr3+ in tumor and liver was the acid mucopolysaccharide (as described concerning 95Zr and 181Hf) whose molecular weight exceeded 40,000, although the main binding substance of 67Ga3+, 111In3+, 169Yb3+ and 167Tm3+ was the acid mucopolysaccharide with a molecular weight of about 10,000.

摘要

46Sc3+和51Cr3+在肿瘤中的摄取率、在肝脏和肿瘤线粒体部分（含溶酶体）中的浓度、在结缔组织（尤其是炎症组织）中的 avid 积累以及这些组织中与它们结合的物质，与67Ga3+、111In3+、169Yb3+、167Tm3+、95Zr4+和181Hf4+的情况基本相似。然而，46Sc3+和51Cr3+在肿瘤和肝脏中的主要结合物质是分子量超过40000的酸性粘多糖（如关于95Zr和181Hf所描述的那样），而67Ga3+、111In3+、169Yb3+和167Tm3+的主要结合物质是分子量约为10000的酸性粘多糖。