Choi Sung Hyouk, Jang Ki Seok, Chung Min Sung
Department of General Surgery, Anatomical Pathology, Hanyang University Medical Center 222, Wangsimni-ro, Seongdong-gu, Seoul, Korea.
Department of Pathology, Hanyang University Medical Center 222, Wangsimni-ro, Seongdong-gu, Seoul, Korea.
Cancer Biomark. 2015;15(3):333-8. doi: 10.3233/CBM-140447.
Idiopathic granulomatous mastitis (IGM) and Tuberculosis mastitis (TM) are rare inflammatory diseases of the breast that can clinically mimic malignancy causing misdiagnosis as breast cancer. We present a rare case of bilateral granulomatous mastitis with a different etiology. An initial lesion developed in the right breast was diagnosed as IGM, which was treated with antibiotics and surgery. A subsequent lesion developed in the contralateral breast 5 months later and was diagnosed as TM, which also completely responded to antituberculosis medication without surgical excision. Differential diagnosis was made using the results of the polymerase chain reaction for tuberculosis (TBC-PCR) of both of the breast lesions in addition to typical pathologic findings of IGM in the right breast and an antituberculosis medication response in the left breast. To the best of our knowledge, this is the first case of bilateral granulomatous mastitis with a different etiology.
特发性肉芽肿性乳腺炎（IGM）和结核性乳腺炎（TM）是罕见的乳腺炎症性疾病，临床上可酷似恶性肿瘤，导致误诊为乳腺癌。我们报告一例病因不同的双侧肉芽肿性乳腺炎罕见病例。右侧乳房最初出现的病变被诊断为IGM，接受了抗生素治疗和手术。5个月后对侧乳房出现后续病变，被诊断为TM，同样对抗结核药物完全有效，无需手术切除。除了右侧乳房IGM的典型病理表现和左侧乳房对抗结核药物的反应外，还利用两个乳房病变的结核聚合酶链反应（TBC-PCR）结果进行鉴别诊断。据我们所知，这是首例病因不同的双侧肉芽肿性乳腺炎病例。
