Ahmad Norashikin, Azizul Hasan Zafarizal Aldrin, Hassan Hazimah Abu, Ahmad Mansor, Zin Wan Yunus Wan Md
Malaysian Palm Oil Board (MPOB), No. 6, Persiaran Institusi.
J Oleo Sci. 2015;64(1):41-9. doi: 10.5650/jos.ess14097. Epub 2014 Dec 16.
Hydrazide derivatives have been synthesized from methyl esters, hydrazones and vegetable oils. They are important due to their diverse applications in pharmaceutical products, detergents as well as in oil and gas industries. The chemical synthesis of fatty hydrazides is well-established; however, only a few publications described the synthesis of fatty hydrazide derivatives, particularly, when produced from refined, bleached and deodorized palm olein. Here, the synthesis and characterization of N,N-dimethyl fatty hydrazides are reported. The N,N-dimethyl fatty hydrazides was successfully synthesized from fatty hydrazides and dimethyl sulfate in the presence of potassium hydroxide with the molar ratio of 1:1:1, 6 hours reaction time and 80℃ reaction temperature in ethanol. The product yield and purity were 22% and 89%, respectively. The fatty hydrazides used were synthesized from refined, bleached and deodorized palm olein with hydrazine monohydrate at pH 12 by enzymatic route. Fourier transform infrared, gas chromatography and nuclear magnetic resonance (NMR) spectroscopy techniques were used to determine the chemical composition of N,N-dimethyl fatty hydrazides. Proton NMR confirmed the product obtained were N,N-dimethyl fatty hydrazides.
酰肼衍生物是由甲酯、腙和植物油合成的。它们因其在药品、洗涤剂以及石油和天然气工业中的多种应用而具有重要意义。脂肪酰肼的化学合成方法已经成熟；然而，只有少数出版物描述了脂肪酰肼衍生物的合成，特别是由精炼、漂白和脱臭棕榈油精生产时。本文报道了N,N-二甲基脂肪酰肼的合成与表征。在氢氧化钾存在下，以1:1:1的摩尔比、6小时的反应时间和80℃的反应温度，在乙醇中由脂肪酰肼和硫酸二甲酯成功合成了N,N-二甲基脂肪酰肼。产物产率和纯度分别为22%和89%。所用的脂肪酰肼是通过酶法由精炼、漂白和脱臭棕榈油精与水合肼在pH 12条件下合成的。采用傅里叶变换红外光谱、气相色谱和核磁共振（NMR）光谱技术来确定N,N-二甲基脂肪酰肼的化学组成。质子核磁共振证实所得到的产物是N,N-二甲基脂肪酰肼。
