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对逆转录病毒血清呈阳性的非洲绿猴外周淋巴细胞增多、出现淋巴样肝炎和贫血。

Increased peripheral lymphocytes, lymphoid hepatitis and anaemia in African vervet monkeys seropositive to retroviruses.

作者信息

Fincham J E, Van der Riet F, Steytler J G, Tung M T, Cooper R, Seier J V, Madden D L, Kanki P, Campbell J A, Taljaard J J

机构信息

Research Institute for Nutritional Diseases of the South African Medical Research Council, Tygerberg.

出版信息

J Comp Pathol. 1989 Jul;101(1):53-68. doi: 10.1016/0021-9975(89)90076-5.

DOI:10.1016/0021-9975(89)90076-5
PMID:2551937
Abstract

Wild-caught African Vervet monkeys are commonly infected by Simian T-lymphotropic virus I (STLV1) and Simian immunodeficiency virus (SIV), yet the natural histories of these infections are largely unknown. Seropositivity was associated with increased total, T and atypical lymphocytes. In seropositive females there was mild, normocytic, normochromic anaemia. Lymphoid hepatitis was present in seven seropositive cases. African Vervets used in biomedical research, vaccine production and organ transplantation research are often infected by exogenous retroviruses which can be oncogenic and immunosuppressive in captive monkeys. Elimination of these infections may be possible by breeding Vervets in captivity.

摘要

野生捕获的非洲绿猴通常感染猴T淋巴细胞嗜性病毒I(STLV1)和猴免疫缺陷病毒(SIV),然而这些感染的自然史在很大程度上尚不清楚。血清阳性与总淋巴细胞、T淋巴细胞和非典型淋巴细胞增多有关。血清阳性的雌性动物存在轻度正细胞正色素性贫血。7例血清阳性病例出现淋巴性肝炎。用于生物医学研究、疫苗生产和器官移植研究的非洲绿猴常被外源性逆转录病毒感染,这些病毒在圈养猴子中可能具有致癌性和免疫抑制作用。通过圈养繁殖绿猴有可能消除这些感染。

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