电针对急性胰腺炎患者炎症反应的影响：一项探索性研究。
Effect of electroacupuncture on the inflammatory response in patients with acute pancreatitis: an exploratory study.
作者信息
Zhu Shi-Feng, Guo Hui, Zhang Rong-Rong, Zhang Yumei, Li Juan, Zhao Xian-Lin, Chen Tian-Rong, Wan Mei-Hua, Chen Guang-Yuan, Tang Wen-Fu
机构信息
Department of Integrative Medicine, Sichuan Center for Pancreatitis, West China Hospital, Sichuan University, Chengdu, Sichuan Province, China.
Second Affiliated Hospital of Shaanxi University of Chinese Medicine, Xianyang, Shaanxi Province, China.
出版信息
Acupunct Med. 2015 Apr;33(2):115-20. doi: 10.1136/acupmed-2014-010646. Epub 2014 Dec 17.
OBJECTIVES
To examine the effects of electroacupuncture (EA) on inflammatory responses in patients with acute pancreatitis (AP).
METHODS
Eighty patients with mild or severe AP were randomly allocated to a control group or an EA group. All patients were managed conservatively. In addition, the EA group received acupuncture for 30 min per day for 7 days at bilateral points ST36, LI4, TE6, ST37 and LR3. Interleukin (IL)-6, IL-10 and C-reactive protein (CRP) levels were measured on admission and on day 7. The time to re-feeding and length of stay in hospital were also recorded.
RESULTS
A total of 58 patients provided complete data. The characteristics of the patients in the EA and control groups were similar. After 7 days the serum concentrations of IL-10 were higher in the EA group than in the control group (mild AP: 6.2±1.2 vs 5.2±0.9 pg/mL, p<0.05; severe AP: 14.9±7.8 vs 7.9±6.3 pg/mL, p<0.05). For patients with severe AP, the CRP level in the EA group was lower than in the control group (p<0.05).
CONCLUSIONS
EA may reduce the severity of AP by inducing anti-inflammatory effects and reducing the time to re-feeding; however, it did not reduce the length of hospital stay.
TRIAL REGISTRATION NUMBER
ChiCTR-TRC-13003572.
目的
探讨电针（EA）对急性胰腺炎（AP）患者炎症反应的影响。
方法
80例轻度或重度AP患者被随机分为对照组和EA组。所有患者均接受保守治疗。此外，EA组患者在双侧足三里（ST36）、合谷（LI4）、外关（TE6）、上巨虚（ST37）和太冲（LR3）穴位每天接受30分钟针刺，共7天。在入院时和第7天测量白细胞介素（IL）-6、IL-10和C反应蛋白（CRP）水平。记录恢复进食时间和住院时间。
结果
共有58例患者提供了完整数据。EA组和对照组患者的特征相似。7天后，EA组患者血清IL-10浓度高于对照组（轻度AP：6.2±1.2 vs 5.2±0.9 pg/mL，p<0.05；重度AP：14.9±7.8 vs 7.9±6.3 pg/mL，p<0.05）。对于重度AP患者，EA组的CRP水平低于对照组（p<0.05）。
结论
EA可能通过诱导抗炎作用和缩短恢复进食时间来降低AP的严重程度；然而，它并未缩短住院时间。
试验注册号
ChiCTR-TRC-13003572。
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