Numahata Kenji, Hoshi Senji, Hoshi Kiyotsugu, Yasuno Nobuhiro, Kubo Maiko, Sasagawa Isoji, Ohta Shoichiro
Department of Urology, Yamagata Prefectural Central Hospital, Yamagata, Japan.
Department of Urology, Yamagata Prefectural Central Hospital, Yamagata, Japan ; Department of Urology, Yamagata Tokushukai Hospital, Yamagata, Japan.
Case Rep Oncol. 2014 Nov 5;7(3):746-50. doi: 10.1159/000369004. eCollection 2014 Sep.
We report a case of primary undifferentiated bladder carcinoma, which revealed a remarkable response to methotrexate, vinblastine, adriamycin, and cisplatin (MVAC) therapy. A 46-year-old Japanese woman presented at the hospital with the chief complaints of gross hematuria and pain during urination. Cystoscopy revealed a large smooth-surfaced tumor in the urinary bladder. The histopathological diagnosis was undifferentiated carcinoma. The patient then received 3 courses of MVAC over a 3-month period. Hydronephrosis disappeared after the first course, and the tumor shrank rapidly. After completion of the third MVAC course, radical cystectomy and ileal conduit surgery were performed. After 7 years, the patient has still had no recurrences or metastases. We retrospectively review the relative efficacy of the two popular chemotherapeutic regimens in the management of muscle-invasive bladder cancer in patients who had had radical cystectomy.
我们报告一例原发性未分化膀胱癌，该病例显示对甲氨蝶呤、长春碱、阿霉素和顺铂（MVAC）疗法有显著反应。一名46岁的日本女性因肉眼血尿和排尿疼痛为主诉入院。膀胱镜检查发现膀胱内有一个大的表面光滑的肿瘤。组织病理学诊断为未分化癌。该患者随后在3个月内接受了3个疗程的MVAC治疗。第一个疗程后肾积水消失，肿瘤迅速缩小。第三个MVAC疗程结束后，进行了根治性膀胱切除术和回肠代膀胱术。7年后，患者仍无复发或转移。我们回顾性地评估了两种常用化疗方案在根治性膀胱切除术后肌肉浸润性膀胱癌患者治疗中的相对疗效。
