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加拿大环境下注射毒品者中处方镇痛药物的拒用情况

Denial of prescription analgesia among people who inject drugs in a Canadian setting.

作者信息

Voon Pauline, Callon Cody, Nguyen Paul, Dobrer Sabina, Montaner Julio S G, Wood Evan, Kerr Thomas

机构信息

British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, Canada.

出版信息

Drug Alcohol Rev. 2015 Mar;34(2):221-8. doi: 10.1111/dar.12226. Epub 2014 Dec 17.

Abstract

INTRODUCTION AND AIMS

Despite the high prevalence of pain among people who inject drugs (PWIDs), clinicians may be reluctant to prescribe opioid-based analgesia to those with a history of drug use or addiction. We sought to examine the prevalence and correlates of PWIDs reporting being denied of prescription analgesia (PA). We also explored reported reasons for and actions taken after being denied PA.

DESIGN AND METHODS

Using data from two prospective cohort studies of PWIDs, multivariate logistic regression was used to identify the prevalence and correlates of reporting being denied PA. Descriptive statistics were used to characterise reasons for denials and subsequent actions.

RESULTS

Approximately two-thirds (66.5%) of our sample of 462 active PWIDs reported having ever been denied PA. We found that reporting being denied PA was significantly and positively associated with having ever been enrolled in methadone maintenance treatment (adjusted odds ratio 1.76, 95% confidence interval 1.11-2.80) and daily cocaine injection (adjusted odds ratio 2.38, 95% confidence interval 1.00-5.66). The most commonly reported reason for being denied PA was being accused of drug seeking (44.0%). Commonly reported actions taken after being denied PA included buying the requested medication off the street (40.1%) or obtaining heroin to treat pain (32.9%).

DISCUSSION AND CONCLUSIONS

These findings highlight the challenges of addressing perceived pain and the need for strategies to prevent high-risk methods of self-managing pain, such as obtaining diverted medications or illicit substances for pain. Such strategies may include integrated pain management guidelines within methadone maintenance treatment and other substance use treatment programs.

摘要

引言与目的

尽管注射吸毒者(PWIDs)中疼痛的患病率很高,但临床医生可能不愿为有吸毒或成瘾史的人开阿片类镇痛药。我们试图研究报告被拒绝处方镇痛药(PA)的注射吸毒者的患病率及其相关因素。我们还探讨了报告的被拒绝PA的原因以及被拒绝后采取的行动。

设计与方法

利用两项注射吸毒者前瞻性队列研究的数据,采用多因素逻辑回归分析来确定报告被拒绝PA的患病率及其相关因素。描述性统计用于描述拒绝的原因和后续行动。

结果

在我们462名活跃的注射吸毒者样本中,约三分之二(66.5%)报告曾被拒绝PA。我们发现,报告被拒绝PA与曾参加美沙酮维持治疗(调整后的优势比为1.76,95%置信区间为1.11 - 2.80)和每日注射可卡因(调整后的优势比为2.38,95%置信区间为1.00 - 5.66)显著正相关。被拒绝PA最常见的报告原因是被指控寻求药物(44.0%)。被拒绝PA后常见的报告行动包括从街头购买所需药物(40.1%)或获取海洛因来治疗疼痛(32.9%)。

讨论与结论

这些发现凸显了应对感知疼痛的挑战以及预防自我管理疼痛的高风险方法的必要性,例如获取用于止痛的转用药物或非法物质。此类策略可能包括在美沙酮维持治疗和其他物质使用治疗项目中纳入综合疼痛管理指南。

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