Kennedy Mary Clare, Kerr Thomas, DeBeck Kora, Dong Huiru, Milloy M-J, Wood Evan, Hayashi Kanna
British Columbia Centre for Excellence in HIV/AIDS, St. Paul's Hospital, Vancouver, BC, Canada.
School of Population and Public Health, University of British Columbia, Vancouver, BC, Canada.
Am J Addict. 2016 Jun;25(4):275-82. doi: 10.1111/ajad.12380. Epub 2016 May 3.
Despite the high prevalence of prescription opioid (PO) misuse, little is known about the phenomenon of seeking POs for nonmedical use among high-risk populations, such as people who inject drugs (PWID). We therefore sought to examine the prevalence and correlates of seeking POs from a physician for nonmedical use among PWID in Vancouver, Canada.
Cross-sectional data from two open prospective cohort studies of PWID in Vancouver were collected between June 2013 and May 2014 (n = 1252). Multivariable logistic regression was used to identify factors associated with seeking POs from physicians for nonmedical use.
Of 1252 participants, 458 individuals (36.6%) reported ever trying to get a PO prescription from a physician for nonmedical use and, of these, 343 (74.9%, comprising 27.4% of the total sample) reported ever being successful. Variables independently and positively associated with PO-seeking behavior included older age (adjusted odds ratio [AOR] = 1.02), Caucasian ethnicity (AOR = 1.38), having ever overdosed (AOR = 1.32), having ever participated in methadone maintenance therapy (AOR = 1.90), having ever dealt drugs (AOR = 1.65), and having ever been refused a prescription for pain medication (AOR = 2.02) (all p < .05).
We observed that PO-seeking behavior was common among this sample of PWID and associated with several markers of higher intensity drug use.
Our findings highlight the need to identify evidence-based public health and clinical strategies to mitigate PO misuse among PWID without compromising care for PWID with legitimate medical concerns. (Am J Addict 2016;25:275-282).
尽管处方阿片类药物(PO)滥用现象普遍,但对于诸如注射吸毒者(PWID)等高危人群中非医疗用途寻求PO的现象知之甚少。因此,我们试图研究加拿大温哥华注射吸毒者中向医生寻求非医疗用途PO的患病率及其相关因素。
在2013年6月至2014年5月期间,收集了温哥华两项针对注射吸毒者的开放性前瞻性队列研究的横断面数据(n = 1252)。采用多变量逻辑回归来确定与向医生寻求非医疗用途PO相关的因素。
在1252名参与者中,458人(36.6%)报告曾试图从医生处获取非医疗用途的PO处方,其中343人(74.9%,占总样本的27.4%)报告曾成功获取。与寻求PO行为独立且呈正相关的变量包括年龄较大(调整后的优势比[AOR]=1.02)、白种人(AOR = 1.38)、曾有过药物过量(AOR = 1.32)、曾参加美沙酮维持治疗(AOR = 1.90)、曾从事毒品交易(AOR = 1.65)以及曾被拒绝开具止痛药物处方(AOR = 2.02)(所有p < 0.05)。
我们观察到在该注射吸毒者样本中,寻求PO行为很常见,并且与更高强度吸毒的几个指标相关。
我们的研究结果凸显了识别基于证据的公共卫生和临床策略的必要性,以减轻注射吸毒者中的PO滥用,同时又不影响对有合理医疗需求的注射吸毒者的治疗。(《美国成瘾杂志》2016年;25:275 - 282)