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Duck hepatitis B virus can tolerate insertion, deletion, and partial frameshift mutation in the distal pre-S region.

作者信息

Li J S, Cova L, Buckland R, Lambert V, Deléage G, Trépo C

机构信息

Unité de Recherche sur les Hepatites, Institut National de la Santé et de la Recherche Médicale U 271, Lyon, France.

出版信息

J Virol. 1989 Nov;63(11):4965-8. doi: 10.1128/JVI.63.11.4965-4968.1989.

DOI:10.1128/JVI.63.11.4965-4968.1989
PMID:2552178
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC251147/
Abstract

In-frame and frameshift mutations were introduced into the pre-S region (1,212 base pairs) of duck hepatitis B virus. The in-frame mutants retained the inserted 12 nucleotides, while the frameshift mutants either reverted to wild type or exhibited a 10-nucleotide compensatory deletion downstream of the original mutation site. Thus, although duck hepatitis B virus has a compact and highly economical genome organization, it can replicate despite alterations of up to 9 amino acid codons in the pre-S and P open reading frames.

摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/251147/dc40eca795f2/jvirol00078-0505-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/251147/3a5d39acda53/jvirol00078-0504-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/251147/430595b1f8c9/jvirol00078-0504-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/251147/dc40eca795f2/jvirol00078-0505-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/251147/3a5d39acda53/jvirol00078-0504-a.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/251147/430595b1f8c9/jvirol00078-0504-b.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/1ec5/251147/dc40eca795f2/jvirol00078-0505-a.jpg

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1
Duck hepatitis B virus can tolerate insertion, deletion, and partial frameshift mutation in the distal pre-S region.
J Virol. 1989 Nov;63(11):4965-8. doi: 10.1128/JVI.63.11.4965-4968.1989.
2
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本文引用的文献

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Nucleotide sequence of a cloned duck hepatitis B virus genome: comparison with woodchuck and human hepatitis B virus sequences.克隆的鸭乙型肝炎病毒基因组的核苷酸序列：与土拨鼠和人类乙型肝炎病毒序列的比较。
J Virol. 1984 Mar;49(3):782-92. doi: 10.1128/JVI.49.3.782-792.1984.
2
Predicted secondary structure similarity in the absence of primary amino acid sequence homology: hepatitis B virus open reading frames.在不存在一级氨基酸序列同源性的情况下预测的二级结构相似性：乙型肝炎病毒开放阅读框
Proc Natl Acad Sci U S A. 1984 May;81(9):2902-6. doi: 10.1073/pnas.81.9.2902.
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Electroblotting of multiple gels: a simple apparatus without buffer tank for rapid transfer of proteins from polyacrylamide to nitrocellulose.
乙型肝炎病毒聚合酶中的间隔结构域：填补空缺还是发挥作用？
J Virol. 2022 May 11;96(9):e0005122. doi: 10.1128/jvi.00051-22. Epub 2022 Apr 12.
4
Unusual Features of Sodium Taurocholate Cotransporting Polypeptide as a Hepatitis B Virus Receptor.牛磺胆酸钠共转运多肽作为乙型肝炎病毒受体的独特特征
J Virol. 2016 Aug 26;90(18):8302-13. doi: 10.1128/JVI.01153-16. Print 2016 Sep 15.
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Active human hepatitis B viral polymerase expressed in rabbit reticulocyte lysate system.在兔网织红细胞裂解物系统中表达的活性人乙肝病毒聚合酶。
Virus Genes. 1999;19(2):123-30. doi: 10.1023/a:1008175107309.
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Previously unsuspected cis-acting sequences for DNA replication revealed by characterization of a chimeric heron/duck hepatitis B virus.通过对嵌合鹭/鸭乙型肝炎病毒的特性分析揭示了先前未被怀疑的DNA复制顺式作用序列。
J Virol. 1996 Dec;70(12):8310-7. doi: 10.1128/JVI.70.12.8310-8317.1996.
7
Characterization of a 120-Kilodalton pre-S-binding protein as a candidate duck hepatitis B virus receptor.将一种120千道尔顿的前S结合蛋白鉴定为鸭乙型肝炎病毒受体候选物。
J Virol. 1996 Sep;70(9):6029-35. doi: 10.1128/JVI.70.9.6029-6035.1996.
8
Detection of DNA polymerase activities associated with purified duck hepatitis B virus core particles by using an activity gel assay.利用活性凝胶分析法检测与纯化的鸭乙型肝炎病毒核心颗粒相关的DNA聚合酶活性。
J Virol. 1993 Nov;67(11):6558-66. doi: 10.1128/JVI.67.11.6558-6566.1993.
9
Coordinate regulation of replication and virus assembly by the large envelope protein of an avian hepadnavirus.禽嗜肝DNA病毒大囊膜蛋白对复制和病毒组装的协同调控
J Virol. 1994 Jul;68(7):4565-71. doi: 10.1128/JVI.68.7.4565-4571.1994.
10
Detection of an RNase H activity associated with hepadnaviruses.与嗜肝DNA病毒相关的核糖核酸酶H活性的检测。
J Virol. 1995 Sep;69(9):5697-704. doi: 10.1128/JVI.69.9.5697-5704.1995.
多凝胶的电转印：一种无需缓冲槽的简易装置，用于将蛋白质从聚丙烯酰胺快速转移至硝酸纤维素膜。
J Biochem Biophys Methods. 1984 Dec;10(3-4):203-9. doi: 10.1016/0165-022x(84)90040-x.
4
Cloned duck hepatitis B virus DNA is infectious in Pekin ducks.克隆的鸭乙型肝炎病毒DNA对北京鸭具有传染性。
J Virol. 1984 Dec;52(3):932-7. doi: 10.1128/JVI.52.3.932-937.1984.
5
Involvement of directly repeated sequences in the generation of deletions of the avian sarcoma virus src gene.直接重复序列参与禽肉瘤病毒src基因缺失的产生。
J Virol. 1983 Aug;47(2):380-2. doi: 10.1128/JVI.47.2.380-382.1983.
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Instability of large direct repeats in retrovirus vectors.逆转录病毒载体中大型直接重复序列的不稳定性。
J Virol. 1987 Mar;61(3):925-7. doi: 10.1128/JVI.61.3.925-927.1987.
8
Biochemical and immunological characterization of the duck hepatitis B virus envelope proteins.鸭乙型肝炎病毒包膜蛋白的生化与免疫特性
J Virol. 1987 Jul;61(7):2280-5. doi: 10.1128/JVI.61.7.2280-2285.1987.
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J Virol. 1988 Oct;62(10):3832-9. doi: 10.1128/JVI.62.10.3832-3839.1988.
10
ANTHEPROT: a package for protein sequence analysis using a microcomputer.ANTHEPROT：一个使用微型计算机进行蛋白质序列分析的软件包。
Comput Appl Biosci. 1988 Aug;4(3):351-6. doi: 10.1093/bioinformatics/4.3.351.