Nazarov Leonid I, Tamm Mikhail V, Avetisov Vladik A, Nechaev Sergei K
Physics Department, M. V. Lomonosov Moscow State University, 119992 Moscow, Russia.
Soft Matter. 2015 Feb 7;11(5):1019-25. doi: 10.1039/c4sm02519a.
A statistical model describing a fine structure of the intra-chromosome maps obtained by a genome-wide chromosome conformation capture method (Hi-C) is proposed. The model combines hierarchical chain folding with a quenched heteropolymer structure of primary chromatin sequences. It is conjectured that the observed Hi-C maps are statistical averages over many different ways of hierarchical genome folding. It is shown that the existence of a quenched primary structure coupled with hierarchical folding induces a full range of features observed in experimental Hi-C maps: hierarchical elements, chess-board intermittency and large-scale compartmentalization.
提出了一种统计模型，该模型描述了通过全基因组染色体构象捕获方法（Hi-C）获得的染色体内图谱的精细结构。该模型将分层链折叠与初级染色质序列的淬火杂聚物结构相结合。据推测，观察到的Hi-C图谱是许多不同层次基因组折叠方式的统计平均值。结果表明，淬火初级结构与分层折叠的存在会诱导实验Hi-C图谱中观察到的一系列特征：分层元素、棋盘间歇性和大规模分隔。
