Murate T, Hasegawa T, Hasegawa Y, Shimokata K
Nihon Kyobu Shikkan Gakkai Zasshi. 1989 Apr;27(4):513-7.
A 62-year-old man was admitted to our hospital because of high serum amylase and neck swelling. His chest radiography revealed a mass lesion in the right upper lung. Open lung biopsy specimen established the pathological diagnosis as intermediate type small cell lung cancer. In his clinical course, obstructive jaundice recurred several times with response to combination chemotherapy. The findings of abdominal echogram, computed tomography and endoscopic retrograde cholangiopancreatography suggested that the jaundice was caused by extrahepatic biliary obstruction with parapancreatic lymph node metastasis. He died of spinal bleeding which spread from the medulla oblongata to the thoracic spinal cord. Bleeding was caused by intramedullary spinal cord metastasis. Both extrahepatic biliary obstruction and intramedullary spinal cord metastasis are rare and their symptoms were more prominent than those of the pulmonary lesion.
一名62岁男性因血清淀粉酶升高和颈部肿胀入院。胸部X线检查显示右上肺有一肿块病变。开胸肺活检标本病理诊断为中间型小细胞肺癌。在其临床病程中,阻塞性黄疸多次复发,联合化疗有效。腹部超声、计算机断层扫描和内镜逆行胰胆管造影检查结果提示黄疸是由肝外胆管梗阻伴胰周淋巴结转移所致。他死于脊髓出血,出血从延髓蔓延至胸段脊髓。出血是由脊髓髓内转移引起的。肝外胆管梗阻和脊髓髓内转移均罕见,且其症状比肺部病变更为突出。