Achille Gaetano, Zizzi Stefania, Di Stasio Enrico, Grammatica Alberto, Grammatica Luciano
Cervico-Facial Ultrasound Diagnostic and Interventional Unit, Institute of Oncology, Bari, Italy.
Ear, Nose, and Throat Unit (ENTU), Institute of Oncology, Bari, Italy.
Head Neck. 2016 May;38(5):677-82. doi: 10.1002/hed.23957. Epub 2015 Jun 24.
Laser ablation may be useful in debulking of benign thyroid nodules.
In order to retrospectively evaluate the effectiveness and safety of laser ablation, 45 patients with benign solid thyroid nodules, with a fluid component ≤20%, were included in our series between October 2009 and January 2011. All reported pressure and/or cosmetic complaints. Nd:YAG laser at 1064 nm was used, with a fix-power (3W), changing the application time. All patients were evaluated at baseline, 6 months, and 12 months and any complications were recorded.
Mean nodule volume reduction decreased from 24.2 mL ± 19.4 to 4.5 ± 5.2 at 12 months (p < .001). Mean nodule volume reduction was 84% ± 13. Cosmetic signs were completely resolved in 87%, reduced in 9%, unchanged in 2%, and pressure symptoms were resolved in 88%. One patient experienced transient dysphonia.
Ultrasound-guided laser ablation is an effective tool for treatment of symptomatic benign thyroid nodules in patients not eligible for surgery.
激光消融术可能有助于缩小良性甲状腺结节的体积。
为了回顾性评估激光消融术的有效性和安全性，我们纳入了2009年10月至2011年1月期间的45例良性实性甲状腺结节患者，其液体成分≤20%。所有患者均报告有压迫感和/或美观方面的问题。使用波长为1064nm的Nd:YAG激光，固定功率（3W），改变照射时间。所有患者在基线、6个月和12个月时接受评估，并记录任何并发症。
12个月时，平均结节体积缩小从24.2mL±19.4降至4.5±5.2（p＜0.001）。平均结节体积缩小率为84%±13%。87%的患者美观问题完全解决，9%有所减轻，2%无变化，88%的患者压迫症状得到缓解。1例患者出现短暂性发音困难。
超声引导下激光消融术是治疗不适于手术的有症状良性甲状腺结节的有效方法。
