Eichstaedt Katie E, Soble Jason R, Kamper Joel E, Bozorg Ali M, Benbadis Selim R, Vale Fernando L, Schoenberg Mike R
University of South Florida, Morsani College of Medicine, 3515 East Fletcher Avenue, MDC Box 14, Tampa, FL 33613, USA.
South Texas Veterans Healthcare System, Psychology Service (116B), 7400 Merton Minter Blvd., San Antonio, TX 78229, USA.
Brain Lang. 2015 Feb;141:11-5. doi: 10.1016/j.bandl.2014.11.013. Epub 2014 Dec 15.
When differences exist, women tend to outperform men on measures of verbal fluency, possibly due to greater bilateral language representation. Patients with temporal lobe epilepsy (TLE) have a higher rate of atypical cortical language representation than the general population, making them a population of interest for the study of language. For the current study, 78 TLE patients (51% male, 51% left temporal focus) underwent pre-surgical neuropsychological evaluations. Retrospective data analyses investigated the impact of seizure laterality and sex on letter and semantic verbal fluency. Results indicated an interaction between sex and laterality for semantic, but not letter, verbal fluency. Males with left TLE exhibited significantly worse semantic fluency than males with right TLE, whereas females' semantic fluency did not differ by seizure focus. These data indicate that females with TLE may indeed engage in more bilateral hemispheric processing of semantic verbal fluency, whereas males may be more reliant on left temporal cortical function for this task.
当存在差异时，女性往往在语言流畅性测试中表现优于男性，这可能是由于双侧语言表征更强。颞叶癫痫（TLE）患者的非典型皮质语言表征发生率高于普通人群，这使他们成为语言研究中一个令人感兴趣的群体。在当前的研究中，78名TLE患者（51%为男性，51%为左侧颞叶病灶）接受了术前神经心理学评估。回顾性数据分析调查了癫痫发作偏侧性和性别对字母和语义语言流畅性的影响。结果表明，在语义语言流畅性方面，性别和偏侧性之间存在交互作用，但在字母语言流畅性方面不存在。左侧TLE的男性语义流畅性明显低于右侧TLE的男性，而女性的语义流畅性在癫痫病灶方面没有差异。这些数据表明，TLE女性在语义语言流畅性方面可能确实会进行更多的双侧半球加工，而男性在这项任务中可能更依赖左侧颞叶皮质功能。
