Liu Lei, Bian Ka
Zhongguo Zhong Yao Za Zhi. 2014 Sep;39(17):3216-20.
Cisplatin is a first-line anticancer drug widely used in clinic. However, its resistance reduces its efficacy. With a non-specific cell cycle, cisplatin's main targets are nucleophilic protein, DNA and RNA in cells. Among cisplatin's multi-factorial resistance mechanisms, abnormal expression of transport protein, intracellular detoxification enhancement, DNA repair capacity increase and apoptosis blocking are the main mechanisms. Because traditional Chinese medicines (TCMs) have unique advantages in cancer treatment, their combination with cisplatin can improve the efficacy. In this paper, the authors summarized the advance in studies on cisplatin's resistance and the combination of TCMs and cisplatin in recent years.
顺铂是临床上广泛使用的一线抗癌药物。然而，其耐药性降低了其疗效。由于顺铂具有非特异性细胞周期，其主要作用靶点是细胞中的亲核蛋白、DNA和RNA。在顺铂的多因素耐药机制中，转运蛋白异常表达、细胞内解毒增强、DNA修复能力增加和凋亡阻断是主要机制。由于中药在癌症治疗中具有独特优势，其与顺铂联合使用可提高疗效。本文作者综述了近年来顺铂耐药性以及中药与顺铂联合应用的研究进展。
