1996 - 2009年瑞士年轻女性乳腺癌：一项基于人群的纵向研究。
Breast cancer in younger women in Switzerland 1996-2009: a longitudinal population-based study.
作者信息
Bodmer Alexandre, Feller Anita, Bordoni Andrea, Bouchardy Christine, Dehler Silvia, Ess Silvia, Levi Fabio, Konzelmann Isabelle, Rapiti Elisabetta, Steiner Annik, Clough-Gorr Kerri M
机构信息
University Hospital Geneva, Rue Gabrielle-Perret-Gentil 4, 1211 Geneva 14, Switzerland.
National Institute for Cancer Epidemiology and Registration (NICER), Seilergraben 49, 8001 Zürich, Switzerland; Institute of Social and Preventive Medicine (ISPM), University of Bern, Finkenhubelweg 11, 3012 Bern, Switzerland.
出版信息
Breast. 2015 Apr;24(2):112-7. doi: 10.1016/j.breast.2014.11.004. Epub 2014 Dec 15.
BACKGROUND
Breast cancer (BC) is the most commonly diagnosed cancer and a leading cause of death in younger women.
METHODS
We analysed incidence, mortality and relative survival (RS) in women with BC aged 20-49 years at diagnosis, between 1996 and 2009 in Switzerland. Trends are reported as estimated annual percentage changes (EAPC).
RESULTS
Our findings confirm a slight increase in the incidence of BC in younger Swiss women during the period 1996-2009. The increase was largest in women aged 20-39 years (EAPC 1.8%). Mortality decreased in both age groups with similar EAPCs. Survival was lowest among women 20-39 years (10-year RS 73.4%). We observed no notable differences in stage of disease at diagnosis that might explain these differences.
CONCLUSIONS
The increased incidence and lower survival in younger women diagnosed with BC in Switzerland indicates possible differences in risk factors, tumour biology and treatment characteristics that require additional examination.
背景
乳腺癌（BC）是最常被诊断出的癌症，也是年轻女性死亡的主要原因。
方法
我们分析了1996年至2009年期间瑞士20至49岁确诊为乳腺癌的女性的发病率、死亡率和相对生存率（RS）。趋势以估计的年百分比变化（EAPC）报告。
结果
我们的研究结果证实，1996年至2009年期间，瑞士年轻女性乳腺癌的发病率略有上升。20至39岁女性的上升幅度最大（EAPC为1.8%）。两个年龄组的死亡率均有所下降，EAPC相似。20至39岁女性的生存率最低（10年相对生存率为73.4%）。我们在诊断时未观察到疾病分期的显著差异，无法解释这些差异。
结论
瑞士年轻乳腺癌患者发病率上升且生存率较低，这表明在风险因素、肿瘤生物学和治疗特征方面可能存在差异，需要进一步研究。
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