Department of Social and Preventive Medicine, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
Department of Health Economics, Center for Public Health, Medical University of Vienna, Kinderspitalgasse 15, 1090, Vienna, Austria.
Sci Rep. 2022 Apr 29;12(1):7048. doi: 10.1038/s41598-022-10560-x.
Breast cancer (BC) is the most commonly diagnosed malignant disease and the leading cause of cancer death in women in Austria. We investigated overall and subgroup-specific female breast cancer rates to provide a comprehensive analysis of trends over several decades. Incidence, mortality, and survival, as well as age-, stage-, and birth cohort-specific incidence were analysed using nationwide cancer registry data on 163,694 cases of female breast cancer in Austria (1983-2017). Annual percentage changes were estimated using joinpoint regression. BC incidence underwent linear increases until 1997 and reversed with statistically non-significant declines until 2017. After initial increases in BC-specific mortality, rates were stable from 1989 through 1995 and started declining thereafter, although statistically non-significantly after 2011. Overall BC-specific survivals, as well as survivals according to the calendar period of diagnosis, increased throughout the observation period. Incidence in younger women (aged 44 and lower) showed linear increases, whereas for women aged 45 and higher mostly stable or decreasing rates were observed. Localised BC incidence increased markedly and started declining only in 2012. Distant disease-BC incidence decreased through the whole observation period and incidence of regionalised BC started declining in 2000. Birth cohort-specific incidence peaked in women born between 1935 and 1949 (ages 45-74). In conclusion, the incidence of BC in younger women is increasing, while overall female BC incidence and mortality are stable with non-significant declines. Further, increases in the incidence of early-stage BC (localised) seem disproportionately high in comparison to more modest decreases in late-stage BC incidence (regionalised and distant disease).
乳腺癌（BC）是奥地利女性最常见的恶性肿瘤，也是导致女性癌症死亡的主要原因。我们研究了总体和亚组特异性的女性乳腺癌发病率，以提供对几十年趋势的全面分析。使用奥地利全国癌症登记处的数据，对 163694 例女性乳腺癌病例的发病率、死亡率和生存率，以及年龄、分期和出生队列特异性发病率进行了分析（1983-2017 年）。使用 joinpoint 回归估计年度百分比变化。BC 发病率呈线性增长，直至 1997 年，此后呈统计学上无显著下降趋势，直至 2017 年。BC 特异性死亡率最初上升后，自 1989 年至 1995 年保持稳定，此后开始下降，尽管 2011 年后无统计学意义。总体 BC 特异性生存率以及根据诊断日历期的生存率在整个观察期内均有所提高。年龄在 44 岁及以下的年轻女性的发病率呈线性增长，而年龄在 45 岁及以上的女性的发病率则观察到稳定或下降。局部 BC 的发病率显著增加，仅在 2012 年开始下降。远处转移 BC 的发病率在整个观察期内持续下降，区域性 BC 的发病率在 2000 年开始下降。特定出生队列的发病率在 1935 年至 1949 年（45-74 岁）出生的女性中达到峰值。总之，年轻女性的 BC 发病率在增加，而总体女性 BC 发病率和死亡率保持稳定，呈非显著下降趋势。此外，早期（局部）BC 发病率的增加似乎与晚期（区域性和远处转移）BC 发病率的适度下降不成比例。
