Salak Djokić B, Spitznagel M B, Pavlović D, Janković N, Parojčić A, Ilić V, Nikolić Djurović M
a Neurology Clinic at Clinical Center of Serbia , Belgrade , Serbia.
J Clin Exp Neuropsychol. 2015;37(1):37-48. doi: 10.1080/13803395.2014.985190. Epub 2014 Dec 18.
Diabetes is associated with cognitive impairments, particularly in executive functioning and memory.
The aim was to describe cognitive functioning in Type 1 (T1DM) and Type 2 (T2DM) diabetes compared to healthy controls in a Serbian sample.
We studied 15 patients with adult onset T1DM (age range 19-60 years), 37 patients with T2DM (age range 50-77 years), and 32 healthy controls (28-78 years). All participants underwent comprehensive neuropsychological assessment.
T2DM subjects exhibited poorer performance than healthy controls in global cognitive performance, as well as verbal learning and memory. After correcting for multiple comparisons, follow-up examination of individual tests showed significantly poorer performance only on Trail Making Test Part B (TMT-B). Effect sizes for T2DM versus healthy controls ranged from medium to large for several cognitive variables, while comparisons between T1DM and the other two groups tended to yield much smaller effects.
T2DM is associated with poorer cognition, particularly in executive functions, learning/memory, and global cognition. Lack of group differences may be due to use of an adult onset T1DM sample, relatively young age of our T2DM sample, or characteristics of healthy control subjects in our Serbian sample.
糖尿病与认知障碍有关，尤其是在执行功能和记忆方面。
目的是在塞尔维亚样本中描述1型糖尿病（T1DM）和2型糖尿病（T2DM）患者与健康对照相比的认知功能。
我们研究了15例成年起病的T1DM患者（年龄范围19 - 60岁）、37例T2DM患者（年龄范围50 - 77岁）和32例健康对照（28 - 78岁）。所有参与者均接受了全面的神经心理学评估。
T2DM患者在整体认知表现以及言语学习和记忆方面的表现比健康对照差。在对多重比较进行校正后，对各个测试的后续检查显示仅在连线测验B部分（TMT - B）表现明显较差。T2DM与健康对照之间几个认知变量的效应大小从中等到大，而T1DM与其他两组之间的比较往往产生小得多的效应。
T2DM与较差的认知有关，尤其是在执行功能、学习/记忆和整体认知方面。缺乏组间差异可能是由于使用了成年起病的T1DM样本、我们的T2DM样本相对年轻的年龄或我们塞尔维亚样本中健康对照受试者的特征。
