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Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.

作者信息

McVey D, Brizuela L, Mohr I, Marshak D R, Gluzman Y, Beach D

机构信息

Cold Spring Harbor Laboratory, New York 11724.

出版信息

Nature. 1989 Oct 12;341(6242):503-7. doi: 10.1038/341503a0.

DOI:10.1038/341503a0
PMID:2552322
Abstract

Simian virus 40 large tumour antigen (T) is a replication origin binding protein required for viral DNA synthesis. Unphosphorylated T antigen is deficient in promoting DNA replication in vitro but can be activated by phosphorylation at residue threonine 124 by the cdc2 protein kinase. This observation demonstrates that T is regulated by phosphorylation and provides a model for cdc2 function in the control of DNA replication.

摘要

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Phosphorylation of large tumour antigen by cdc2 stimulates SV40 DNA replication.
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