Institute of Medical Biometry and Informatics, University of Heidelberg, Heidelberg, Germany.
Division of Clinical Epidemiology and Aging Research, German Cancer Research Center (DKFZ), Heidelberg, Germany.
Gastrointest Endosc. 2015 Mar;81(3):646-654.e1. doi: 10.1016/j.gie.2014.09.049. Epub 2014 Dec 16.
The adenoma detection rate (ADR) is an important surrogate measure of performance quality for screening colonoscopies.
To demonstrate how physicians with unusual performance concerning the adenoma detection rate may be identified in screening colonoscopy databases.
Bayesian random-effects modeling and Winsorization of potential outliers were applied to develop a robust model for the majority of providers. Divergence was assessed with adjustment for multiple testing. The steps in the analysis were visualized by using funnel plots. Additionally, minimum requirements for the number of colonoscopies with 1 or more detected adenomas were derived.
Data from 422 physicians offering screening colonoscopy and participating in a quality assurance program in Bavaria, Germany, were used.
A total of 69,738 asymptomatic individuals 55 to 79 years of age.
Screening colonoscopy.
Physician-specific ADRs.
The overall ADR in the sample was 26%. From an initial model, 62 physicians (15%) were identified as potential outliers. A model with normally distributed random effects was then chosen as the robust null model. Of the potential outliers, 10 (16%) were confirmed as physicians with unusual performance at a false discovery rate of 5%. For all of them, the observed ADR was lower than expected, and together they accounted for 1.4% of all included colonoscopies.
Analysis of routine data.
The applied statistical approach appears suitable to identify unusual performance in screening colonoscopy databases. Its application may help to evaluate and improve the quality of colonoscopy in population-based colorectal cancer screening programs.
腺瘤检出率(ADR)是筛查结肠镜检查性能质量的重要替代指标。
展示如何在筛查结肠镜检查数据库中识别腺瘤检出率异常的医生。
贝叶斯随机效应模型和潜在异常值的温莎化被应用于为大多数提供者开发稳健的模型。通过调整多重检验来评估偏差。通过使用漏斗图可视化分析步骤。此外,还得出了具有 1 个或多个检测到的腺瘤的结肠镜检查数量的最低要求。
使用来自德国巴伐利亚州提供筛查结肠镜检查并参与质量保证计划的 422 名医生的数据。
共有 69738 名 55 至 79 岁无症状个体。
筛查结肠镜检查。
医师特异性 ADR。
样本中的总体 ADR 为 26%。从初始模型中,确定了 62 名(15%)医生为潜在异常值。然后选择具有正态分布随机效应的模型作为稳健的零模型。在潜在异常值中,有 10 名(16%)被确认为表现异常的医生,假发现率为 5%。对于所有人来说,观察到的 ADR 均低于预期,他们共占所有纳入结肠镜检查的 1.4%。
分析常规数据。
所应用的统计方法似乎适合识别筛查结肠镜检查数据库中的异常表现。其应用有助于评估和改善基于人群的结直肠癌筛查计划中结肠镜检查的质量。