来自四只圈养 drills（白颊长臂猿）的近全长 SIVdrl 基因组的遗传特征分析

Genetic characterization of near full length SIVdrl genomes from four captive drills (Mandrillus leucophaeus).

作者信息

Dietrich Ursula, Landersz Margot, Stahl-Hennig Christiane, Geiger Christina, Foley Brian T

机构信息

1 Georg-Speyer-Haus, Institute for Tumor Biology and Experimental Therapy , Frankfurt, Germany .

出版信息

AIDS Res Hum Retroviruses. 2015 Mar;31(3):353-7. doi: 10.1089/AID.2014.0244. Epub 2015 Jan 21.

DOI:10.1089/AID.2014.0244

PMID:25523403

Abstract

We sequenced near full length SIVdrl genomes from four captive drills (Mandrillus leucophaeus). All four animals were born in captivity in German zoos. Although serologically SIV negative before acquisition in zoo A in 2008 and 2009, during a routine analysis all four animals were determined to be SIV antibody positive in 2011. Comparisons of the four new SIVdrl sequences showed high identity among each other (90.7-97.7% in env) and to the only published full length sequence SIVdrl FAO (90.5-92.8% in env), which is also derived from a captive drill. SIVdrl infections seem to be highly prevalent in captive drills, probably resulting from frequent animal transfers between the zoos in an effort to maintain this highly endangered species and its genetic diversity. This should be kept in mind as SIVdrl may be transmitted to uninfected animals in open groups and potentially also to animal keepers having contact with these nonhuman primates.

摘要

我们对来自四只圈养 drills（白颊长臂猿）的近全长 SIVdrl 基因组进行了测序。这四只动物均出生于德国动物园的圈养环境。尽管在 2008 年和 2009 年被引入动物园 A 之前血清学检测显示 SIV 呈阴性，但在 2011 年的一次常规分析中，这四只动物均被确定为 SIV 抗体阳性。对这四个新的 SIVdrl 序列进行比较发现，它们彼此之间具有高度的同一性（env 区域为 90.7 - 97.7%），并且与唯一已发表的全长序列 SIVdrl FAO（env 区域为 90.5 - 92.8%）也具有高度同一性，SIVdrl FAO 同样来自一只圈养的 drills。SIVdrl 感染在圈养的 drills 中似乎非常普遍，这可能是由于动物园之间频繁的动物转移，以维持这种高度濒危物种及其遗传多样性。鉴于 SIVdrl 可能在开放群体中传播给未感染的动物，并且潜在地也会传播给与这些非人类灵长类动物接触的动物饲养员，这一点应予以重视。