van Rensburg E J, Engelbrecht S, Mwenda J, Laten J D, Robson B A, Stander T, Chege G K
Department of Medical Virology, University of Stellenbosch and Tygerberg Hospital, South Africa.
J Gen Virol. 1998 Jul;79 ( Pt 7):1809-14. doi: 10.1099/0022-1317-79-7-1809.
Simian immunodeficiency viruses (SIVs) have been shown to infect many Old World African primate species. Thus far, no work has been published on southern African primates. In this study we investigated the genetic diversity between SIV strains from Kenyan and South African vervets (Cercopithecus aethiops pygerythrus). We amplified and sequenced a 1113 bp region of the env gene. Phylogenetic analysis of these sequences showed that all strains clustered with members of the vervet subgroup of SIVagm. The SIVs from South African vervets differed by 7% from each other and by 8-14% from the Kenyan SIV strains, while the Kenyan SIV strains differed by 10-21% from SIVagm of other east African vervets. We also isolated and sequenced, for the first time, a SIV strain from a healthy chacma baboon (Papio ursinus), caught in South Africa. Phylogenetic analysis of the env region showed the virus to be closely related to the South African vervet SIV strains, while analysis of its pol region confirmed the virus to be a SIVagm variant.
猿猴免疫缺陷病毒（SIVs）已被证明可感染许多非洲旧大陆灵长类物种。迄今为止，尚未有关于南部非洲灵长类动物的相关研究发表。在本研究中，我们调查了来自肯尼亚和南非绿猴（Cercopithecus aethiops pygerythrus）的SIV毒株之间的遗传多样性。我们扩增并测序了env基因的一个1113bp区域。对这些序列的系统发育分析表明，所有毒株都与SIVagm绿猴亚组的成员聚类。来自南非绿猴的SIV毒株彼此之间相差7%，与肯尼亚的SIV毒株相差8%-14%，而肯尼亚的SIV毒株与其他东非绿猴的SIVagm相差10%-21%。我们还首次从在南非捕获的一只健康的南非大狒狒（Papio ursinus）中分离并测序了一株SIV毒株。对env区域的系统发育分析表明，该病毒与南非绿猴的SIV毒株密切相关，而对其pol区域的分析证实该病毒是一种SIVagm变体。
