抗惊厥药的生理和代谢方面
Physiologic and metabolic aspects of anticonvulsants.
作者信息
Matsuda I, Higashi A, Inotsume N
机构信息
Kumamoto University Medical School, Japan.
出版信息
Pediatr Clin North Am. 1989 Oct;36(5):1099-111. doi: 10.1016/s0031-3955(16)36760-8.
A great number of anticonvulsants are available for treating these different types of epilepsy. Therapeutic drug monitoring has been favored as the method for controlling drug concentrations in the plasma and preventing untoward effects. When these anticonvulsants are prescribed to treat epilepsy in children, careful monitoring is most important because drug metabolism varies depending on maturation and development of body functions. Molecular approaches are also important to elucidate the effectiveness of the drugs for treatment of different seizure disorders and should contribute to a better understanding of body functions.
有大量的抗惊厥药物可用于治疗这些不同类型的癫痫。治疗药物监测已成为控制血浆中药物浓度和预防不良反应的首选方法。当这些抗惊厥药物被用于治疗儿童癫痫时，仔细监测至关重要，因为药物代谢会因身体功能的成熟和发育而有所不同。分子方法对于阐明药物治疗不同癫痫发作障碍的有效性也很重要，并且应该有助于更好地理解身体功能。
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