Polak David, Martin Conchita, Sanz-Sánchez Ignacio, Beyth Nurit, Shapira Lior
Department of Periodontology, Hebrew University-Hadassah Faculty of Dental Medicine, Jerusalem, Israel.
J Clin Periodontol. 2015 Apr;42 Suppl 16:S139-51. doi: 10.1111/jcpe.12340.
Systematically review the scientific evidence for efficiency of anti-inflammatory agents against gingivitis, either as solo treatments or adjunctive therapies.
A protocol was developed aimed to answer the following focused question: "Are anti-inflammatory agents effective in treating gingivitis as solo or adjunct therapies?" RCTs and cohort studies on anti-inflammatory agents against gingivitis studies were searched electronically. Screening, data extraction and quality assessment were conducted. The primary outcome measures were indices of gingival inflammation. A sub-analysis was performed dividing the active agents into anti-inflammatory and other drugs.
The search identified 3188 studies, of which 14 RCTs met the inclusion criteria. The use of anti-inflammatory or other agents, in general showed a higher reduction in the test than in the control in terms of gingival indexes and bleeding scores. Only two RCTs on inflammatory drugs could be meta-analysed, showing a statistically significant reduction in the GI in the experimental group [WMD = -0.090; 95% CI (-0.105; -0.074); p = 0.000]. However, the contribution of both studies to the global result was unbalanced (% weight: 99.88 and 0.12 respectively).
Most of the tested material showed beneficial effect as anti-inflammatory agents against gingivitis, either as a single treatment modality or as an adjunctive therapy.
系统评价抗炎药物单独治疗或辅助治疗牙龈炎有效性的科学证据。
制定一项方案，旨在回答以下重点问题：“抗炎药物单独使用或作为辅助治疗对治疗牙龈炎是否有效？”通过电子检索关于抗炎药物治疗牙龈炎的随机对照试验（RCT）和队列研究。进行筛选、数据提取和质量评估。主要结局指标为牙龈炎症指数。将活性剂分为抗炎药和其他药物进行亚组分析。
检索到3188项研究，其中14项RCT符合纳入标准。总体而言，在牙龈指数和出血评分方面，使用抗炎药或其他药物时，试验组的降低幅度高于对照组。仅有两项关于抗炎药物的RCT可进行荟萃分析，结果显示试验组的牙龈指数有统计学意义的降低[加权均数差（WMD）=-0.090；95%置信区间（CI）（-0.105；-0.074）；p = 0.000]。然而，两项研究对总体结果的贡献不均衡（权重百分比分别为99.88和0.12）。
大多数受试材料作为抗炎药物单独治疗或辅助治疗牙龈炎均显示出有益效果。
