Mekhemar Mohamed, Geib Mathias, Kumar Manoj, Hassan Yasmine, Dörfer Christof
Clinic for Conservative Dentistry and Periodontology, School of Dental Medicine, Christian-Albrecht's University, 24105 Kiel, Germany.
Dr. Geib Private Dental Clinic, Frankfurter Landstraße 79, 61352 Bad Homburg, Germany.
Antioxidants (Basel). 2021 Apr 30;10(5):712. doi: 10.3390/antiox10050712.
(SP) extract, displays very valuable biotherapeutic capacities such as antimicrobial, antioxidant, antiparasitic and anti-inflammatory effects. Numerous investigations have studied the pharmacologic actions of SP in oral disease therapies but its promising outcomes in periodontal health and treatment are not yet entirely described. The current study has been planned to analyze the reported effects of SP as a support to periodontal therapy to indorse regeneration and healing. In consort with clinical trials, in vitro investigations show the advantageous outcomes of SP adjunctive to periodontal treatment. Yet, comprehensive supplementary preclinical and clinical investigations at molecular and cellular levels are indispensable to reveal the exact therapeutic mechanisms of SP and its elements for periodontal health and therapy.
（SP）提取物具有非常有价值的生物治疗能力，如抗菌、抗氧化、抗寄生虫和抗炎作用。许多研究已经探讨了SP在口腔疾病治疗中的药理作用，但其在牙周健康和治疗方面的良好效果尚未得到充分描述。本研究旨在分析SP作为牙周治疗辅助手段对促进再生和愈合的作用。与临床试验一致，体外研究表明SP辅助牙周治疗具有良好效果。然而，在分子和细胞水平上进行全面的补充临床前和临床研究对于揭示SP及其成分对牙周健康和治疗的确切治疗机制是必不可少的。
