Crépet A, Papadopoulos A, Elegbede C F, Ait-Dahmane S, Loynet C, Millet G, Van Der Brempt X, Bruyère O, Marette S, Moneret-Vautrin D A
Risk Assessment Department (DER), French Agency for Food, Environmental and Occupational Health Safety (ANSES), Maisons-Alfort, France.
Risk Assessment Department (DER), French Agency for Food, Environmental and Occupational Health Safety (ANSES), Maisons-Alfort, France.
Regul Toxicol Pharmacol. 2015 Mar;71(2):178-83. doi: 10.1016/j.yrtph.2014.12.006. Epub 2014 Dec 15.
Food allergy is a major public health issue. However, no regulatory measures exist when allergens are present at trace levels and the different risk components are poorly described. Thus, knowledge on exposure components such as the allergens present in foods and the consumption behaviour of allergic consumers and models to estimate the related risk need to be enriched. Mirabel proposes for the first time studying each risk component using an integrated approach in order to improve the quality of life of the allergic population. Field surveys were conducted in order to fill in the current gaps in unintentional allergen traces in food, allergic consumers' food behaviour, threshold doses of allergic reaction, allergy symptoms and severity. The aim is also to propose methodological and operational tools to quantify allergic risk, to test management scenarios and to produce a cost/benefit analysis. Medical data on the peanut allergies of 785 patients were collected in the MIRABEL survey and 443 patients answered the food consumption questionnaire. The population surveyed was mostly paediatric - 86% were children under 16 years of age, with a high percentage of males (60%). This project will generate tangible results on peanut allergen exposure and risk which could be used in future risk assessment work and particularly to provide science-based guidance to set up concentration limits for peanut traces on packages.
食物过敏是一个重大的公共卫生问题。然而，当过敏原以痕量水平存在且不同风险成分描述不佳时，不存在监管措施。因此，关于暴露成分（如食物中存在的过敏原、过敏消费者的消费行为）的知识以及估计相关风险的模型需要得到丰富。米拉贝尔首次提议采用综合方法研究每个风险成分，以提高过敏人群的生活质量。开展了实地调查，以填补目前在食物中无意出现的过敏原痕迹、过敏消费者的食物行为、过敏反应阈值剂量、过敏症状及严重程度方面的空白。其目的还在于提出量化过敏风险的方法和操作工具，测试管理方案并进行成本效益分析。在米拉贝尔调查中收集了785名患者的花生过敏医学数据，443名患者回答了食物消费问卷。被调查人群主要是儿童——86%为16岁以下儿童，男性比例很高（60%）。该项目将在花生过敏原暴露和风险方面产生切实成果，可用于未来的风险评估工作，特别是为设定包装上花生痕迹的浓度限值提供基于科学的指导。
