Liu Liping, Li Guangrun, Sun Yuemei, Li Jian, Tang Ningbo, Dong Liang
Department of Pulmonary Diseases, Qilu Hospital, Shandong University, Jinan, PR China; Department of Allergy, Yuhuangding Hospital, Yantai, Shandong, PR China.
Yuhuangding Hospital, Yantai, Shandong, PR China.
Respir Med. 2015 Mar;109(3):339-46. doi: 10.1016/j.rmed.2014.11.011. Epub 2014 Dec 9.
Little was known about Airway wall thickness of asthma patients with different allergen allergy. So we explored the possible difference of Airway wall thickness of asthma patients mono-sensitized to weed pollen or HDM using high-resolution computed tomography.
85 severe asthma patients were divided into weed pollen group and HDM group according to relevant allergen. 20 healthy donors served as controls. Airway wall area, percentage wall area and luminal area at the trunk of the apical bronchus of the right upper lobe were quantified using HRCT and compared. The values of pulmonary function were assessed as well.
There were differences between HDM group and weed pollen group in WA/BSA,WA% and FEF25-75% pred, and no significant difference in FEV1%pred, FEV1/FVC and LA/BSA. In weed pollen group, WA/BSA was observed to correlate with the duration of rhinitis, whereas in HDM group, WA/BSA and LA/BSA was observed to correlate with the duration of asthma. In weed pollen group, FEV1/FVC showed a weak but significant negative correlation with WA%, but in HDM group FEV1/FVC showed a significant positive correlation with WA% and a statistical negative correlation with LA/BSA. FEV1/FVC and FEF25-75% pred were higher and WA/BSA and LA/BSA were lower in healthy control group than asthma group. FEV1%pred and WA% was no significant difference between asthma patients and healthy subjects.
There are differences between HDM mono-sensitized subjects and weed pollen mono-sensitized subjects, not only in airway wall thickness, but also small airway obstruction.
对于不同过敏原过敏的哮喘患者气道壁厚度了解甚少。因此，我们使用高分辨率计算机断层扫描探索对杂草花粉或屋尘螨单致敏的哮喘患者气道壁厚度的可能差异。
85例重度哮喘患者根据相关过敏原分为杂草花粉组和屋尘螨组。20名健康供者作为对照。使用高分辨率计算机断层扫描对右上叶尖段支气管主干的气道壁面积、壁面积百分比和管腔面积进行量化并比较。同时评估肺功能值。
屋尘螨组和杂草花粉组在气道壁面积/体表面积（WA/BSA）、壁面积百分比（WA%）和第25%~75%用力呼气流量占预计值百分比（FEF25-75%pred）方面存在差异，而在第1秒用力呼气容积占预计值百分比（FEV1%pred）、FEV1/用力肺活量（FEV1/FVC）和管腔面积/体表面积（LA/BSA）方面无显著差异。在杂草花粉组中，观察到WA/BSA与鼻炎病程相关，而在屋尘螨组中，观察到WA/BSA和LA/BSA与哮喘病程相关。在杂草花粉组中，FEV1/FVC与WA%呈弱但显著的负相关，但在屋尘螨组中，FEV1/FVC与WA%呈显著正相关且与LA/BSA呈统计学负相关。健康对照组的FEV1/FVC和FEF25-75%pred高于哮喘组，WA/BSA和LA/BSA低于哮喘组。哮喘患者和健康受试者之间的FEV1%pred和WA%无显著差异。
对屋尘螨单致敏的受试者和对杂草花粉单致敏的受试者之间不仅在气道壁厚度上存在差异，在小气道阻塞方面也存在差异。
