Department of Biochemistry, Nencki Institute of Experimental Biology, Warsaw, Poland.
Eur J Clin Invest. 2015 Jan;45 Suppl 1:25-31. doi: 10.1111/eci.12364.
The adaptor protein p66Shc links membrane receptors to intracellular signalling pathways and has the potential to respond to energy status changes and regulate mitogenic signalling. Initially reported to mediate growth signals in normal and cancer cells, p66Shc has also been recognized as a pro-apoptotic protein involved in the cellular response to oxidative stress. Moreover, it is a key element in processes such as cancer cell proliferation, tumor progression, metastasis and metabolic reprogramming. Recent findings on the role of p66Shc in the above-mentioned processes have been obtained through the use of various tumor cell types, including prostate, breast, ovarian, lung, colon, skin and thyroid cancer cells. Interestingly, the impact of p66Shc on the proliferation rate was mainly observed in prostate tumors, while its impact on metastasis was mainly found in breast cancers. In this review, we summarize the current knowledge about the possible roles of p66Shc in different cancers.
衔接蛋白 p66Shc 将膜受体与细胞内信号通路联系起来，具有响应能量状态变化和调节有丝分裂信号的潜力。最初报道 p66Shc 在正常和癌细胞中介导生长信号，它也被认为是一种参与细胞对氧化应激反应的促凋亡蛋白。此外，它是癌症细胞增殖、肿瘤进展、转移和代谢重编程等过程中的关键因素。通过使用各种肿瘤细胞类型，包括前列腺癌、乳腺癌、卵巢癌、肺癌、结肠癌、皮肤癌和甲状腺癌细胞，最近发现了 p66Shc 在上述过程中的作用。有趣的是，p66Shc 对增殖率的影响主要在前列腺肿瘤中观察到，而对转移的影响主要在乳腺癌中发现。在这篇综述中，我们总结了 p66Shc 在不同癌症中可能发挥的作用的最新知识。
