抗菌羧甲基纤维素/氧化锌纳米复合水凝胶的合成与表征。
Synthesis and characterization of antibacterial carboxymethyl cellulose/ZnO nanocomposite hydrogels.
机构信息
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
Research Laboratory of Dendrimers and Nanopolymers, Faculty of Chemistry, University of Tabriz, P.O. Box 51666, Tabriz, Iran.
出版信息
Int J Biol Macromol. 2015 Mar;74:136-41. doi: 10.1016/j.ijbiomac.2014.11.032. Epub 2014 Dec 15.
In this study, carboxymethyl cellulose/ZnO nanocomposite hydrogels have been synthesized through the in situ formation of ZnO nanoparticles within swollen carboxymethyl cellulose hydrogels. The formation of ZnO nanoparticles in the hydrogels was confirmed using X-ray diffraction, UV-vis spectroscopy and scanning electron microscopy (SEM) studies. SEM micrographs revealed the formation of ZnO nanoparticles with size range of 10-20 nm within the hydrogel matrix. The prepared nanocomposite hydrogels showed a pH and salt sensitive swelling behavior. The ZnO nanocomposite hydrogels have rather higher swelling in different aqueous solutions in comparison with neat hydrogel. The nanocomposite hydrogels demonstrated antibacterial effects against Escherichia coli and Staphylococcus aureus bacteria. The developed carboxymethyl cellulose/ZnO nanocomposite hydrogels can be used effectively for biomedical application.
在这项研究中，通过在溶胀的羧甲基纤维素水凝胶中原位形成氧化锌纳米粒子，合成了羧甲基纤维素/氧化锌纳米复合材料水凝胶。通过 X 射线衍射、紫外-可见光谱和扫描电子显微镜（SEM）研究证实了水凝胶中氧化锌纳米粒子的形成。SEM 显微照片显示，在水凝胶基质内形成了尺寸范围为 10-20nm 的氧化锌纳米粒子。所制备的纳米复合材料水凝胶表现出 pH 和盐敏感的溶胀行为。与纯水凝胶相比，纳米复合材料水凝胶在不同的水溶液中具有更高的溶胀度。纳米复合材料水凝胶对大肠杆菌和金黄色葡萄球菌表现出抗菌作用。开发的羧甲基纤维素/氧化锌纳米复合材料水凝胶可有效地用于生物医学应用。
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