Koksal Deniz, Safak Ozge, Ozcan Aysenaz, Agackiran Yetkin, Erturk Hakan, Findik Gokturk
Department of Chest Diseases, Hacettepe University Medical Faculty, Ankara, Turkey
Department of Chest Diseases, Ataturk Chest Diseases and Chest Surgery Education and Research Hospital, Ankara, Turkey.
Clin Appl Thromb Hemost. 2016 May;22(4):390-4. doi: 10.1177/1076029614564861. Epub 2014 Dec 18.
Malignant pleural mesothelioma (MPM) increases the risk of thromboembolic events (TEEs). In this retrospective study, we aimed to determine the rate of TEEs in MPM and investigate its relationship with the presence of thrombocytosis, the disease stage, and the tumor histopathology.
The study included 178 patients who were histopathologically diagnosed as MPM between the years January 2008 and June 2014.
The mean age was 58.7 ± 11.8 years, and the median follow-up time was 8 months. Seventy-one patients (39.9%) had thrombocytosis (>350 × 10(3)/mL). In total, 14 (7.9%) TEEs were identified: 6 (3.4%) pulmonary thromboembolism, 6 (3.4%) deep venous thrombosis, and 2 (1.1%) myocardial infarctions. Although 5 (2.8%) of the TEEs preceded the diagnosis of MPM, 1 (0.6%) occurred simultaneously with the diagnosis of MPM and 8 (4.5%) followed the diagnosis of MPM. Thromboembolic event rates were not statistically different based on the presence of thrombocytosis (P = .51), disease stage (P = .14), and histopathology (P = .38).
The rate of TEEs was 7.9%. Presence of thrombocytosis, disease stage, and histopathology did not affect the incidence of TEEs.
恶性胸膜间皮瘤（MPM）会增加血栓栓塞事件（TEE）的风险。在这项回顾性研究中，我们旨在确定MPM患者中TEE的发生率，并研究其与血小板增多症、疾病分期和肿瘤组织病理学之间的关系。
该研究纳入了2008年1月至2014年6月期间经组织病理学诊断为MPM的178例患者。
平均年龄为58.7±11.8岁，中位随访时间为8个月。71例患者（39.9%）存在血小板增多症（>350×10³/mL）。共发现14例（7.9%）TEE：6例（3.4%）为肺血栓栓塞，6例（3.4%）为深静脉血栓形成，2例（1.1%）为心肌梗死。虽然5例（2.8%）TEE发生在MPM诊断之前，1例（0.6%）与MPM诊断同时发生，8例（4.5%）在MPM诊断之后发生。基于血小板增多症的存在（P = 0.51）、疾病分期（P = 0.14）和组织病理学（P = 0.38），血栓栓塞事件发生率无统计学差异。
TEE的发生率为7.9%。血小板增多症、疾病分期和组织病理学不影响TEE的发生率。
