McGowan Amy, Silvestri Giuliana, Moore Evelyn, Silvestri Vittorio, Patterson Christopher C, Maxwell Alexander P, McKay Gareth J
Centre for Public Health, Queen's University Belfast, Belfast, Northern Ireland.
Centre for Experimental Medicine, Queen's University Belfast, Belfast, Northern Ireland.
Invest Ophthalmol Vis Sci. 2014 Dec 18;56(1):382-7. doi: 10.1167/iovs.14-15523.
To evaluate the relationship between retinal vascular caliber (RVC), iris color, and age-related macular degeneration (AMD) in elderly Irish nuns.
Data from 1233 participants in the cross-sectional observational Irish Nun Eye Study were assessed from digital photographs with a standardized protocol using computer-assisted software. Macular images were graded according to the modified Wisconsin Age-related Maculopathy Grading System. Regression models were used to assess associations, adjusting for age, mean arterial blood pressure, body mass index, refraction, and fellow RVC.
In total, 1122 (91%) participants had gradable retinal images of sufficient quality for vessel assessment (mean age: 76.3 years [range, 56-100 years]). In an unadjusted analysis, we found some support for a previous finding that individuals with blue iris color had narrower retinal venules compared to those with brown iris color (P < 0.05), but this was no longer significant after adjustment. Age-related macular degeneration status was categorized as no AMD, any AMD, and late AMD only. Individuals with any AMD (early or late AMD) had significantly narrower arterioles and venules compared to those with no AMD in an unadjusted analysis, but this was no longer significant after adjustment. A nonsignificant reduced risk of any AMD or late AMD only was observed in association with brown compared to blue iris color, in both unadjusted and adjusted analyses.
Retinal vascular caliber was not significantly associated with iris color or early/late AMD after adjustment for confounders. A lower but nonsignificant AMD risk was observed in those with brown compared to blue iris color.
评估爱尔兰老年修女的视网膜血管管径（RVC）、虹膜颜色与年龄相关性黄斑变性（AMD）之间的关系。
采用标准化方案，通过计算机辅助软件从数码照片中评估爱尔兰修女眼部横断面观察性研究中1233名参与者的数据。黄斑图像根据改良的威斯康星年龄相关性黄斑病变分级系统进行分级。使用回归模型评估相关性，并对年龄、平均动脉血压、体重指数、屈光状态和对侧RVC进行校正。
共有1122名（91%）参与者有质量足够用于血管评估的可分级视网膜图像（平均年龄：76.3岁[范围56 - 100岁]）。在未校正分析中，我们发现一些证据支持之前的一项研究结果，即蓝色虹膜颜色的个体与棕色虹膜颜色的个体相比，视网膜静脉较窄（P < 0.05），但校正后这一差异不再显著。年龄相关性黄斑变性状态分为无AMD、任何AMD和仅晚期AMD。在未校正分析中，任何AMD（早期或晚期AMD）患者的小动脉和小静脉显著窄于无AMD患者，但校正后这一差异不再显著。在未校正和校正分析中，与蓝色虹膜颜色相比，棕色虹膜颜色的个体发生任何AMD或仅晚期AMD的风险降低，但差异无统计学意义。
校正混杂因素后，视网膜血管管径与虹膜颜色或早期/晚期AMD无显著相关性。与蓝色虹膜颜色相比，棕色虹膜颜色个体的AMD风险较低，但差异无统计学意义。
