Chin You Chuen, Wong Tien Yin, Cheung Chui Ming Gemmy, Cheung Carol Yim-Lui, Zheng Yingfeng, Mitchell Paul, Huang HuiQi, Wang Jie Jin, Ikram Mohammad Kamran
Singapore Eye Research Institute, Singapore National Eye Centre , Singapore .
Ophthalmic Epidemiol. 2014 Aug;21(4):224-9. doi: 10.3109/09286586.2014.926941. Epub 2014 Jun 19.
To examine the association between retinal vascular caliber and early age-related macular degeneration (AMD) in an Indian population.
A total of 3112 Indian participants aged ≥40 years from the population-based Singapore Indian Eye Study who had data available on retinal vascular caliber measurements and AMD status were included. Retinal arteriolar and venular calibers were measured from digital photographs using computer-assisted software according to a standardized protocol. Images of the macular region were graded according to the modified Wisconsin age-related maculopathy grading system. Right eyes were selected for analyses. Binary logistic regression models were used to assess the association, adjusting for age, sex, systolic blood pressure, total cholesterol, random blood glucose, body mass index, and the companion retinal vascular caliber.
A total of 107 participants (3.4%) were diagnosed with early AMD. Neither arteriolar nor venular caliber was related to AMD. For early AMD, the age-, sex-, and companion retinal vascular caliber-adjusted odds ratio (OR) per standard deviation (SD) decrease in arteriolar caliber was 0.95 (95% CI 0.84-1.31; p = 0.671), and per SD increase in venular caliber was OR: 0.96 (95% CI: 0.77-1.20); p = 0.714. No trend was found after categorizing retinal vascular calibers into quartiles. Multivariate adjustment and stratified analyses did not alter these results.
Retinal vascular calibers were not related to early AMD among Indian participants. These findings differ from those of several previous studies performed in Caucasian and Asian populations.
在印度人群中研究视网膜血管管径与早期年龄相关性黄斑变性（AMD）之间的关联。
纳入了基于人群的新加坡印度人眼研究中3112名年龄≥40岁且有视网膜血管管径测量数据和AMD状态数据的印度参与者。根据标准化方案，使用计算机辅助软件从数码照片中测量视网膜小动脉和小静脉管径。黄斑区图像根据改良的威斯康星年龄相关性黄斑病变分级系统进行分级。选择右眼进行分析。使用二元逻辑回归模型评估这种关联，并对年龄、性别、收缩压、总胆固醇、随机血糖、体重指数和伴随的视网膜血管管径进行校正。
共有107名参与者（3.4%）被诊断为早期AMD。小动脉和小静脉管径均与AMD无关。对于早期AMD，在校正年龄、性别和伴随的视网膜血管管径后，小动脉管径每降低1个标准差（SD）的优势比（OR）为0.95（95%可信区间[CI]：0.84 - 1.31；p = 0.671），小静脉管径每增加1个SD的OR为：0.96（95% CI：0.77 - 1.20）；p = 0.714。将视网膜血管管径分为四分位数后未发现趋势。多变量校正和分层分析未改变这些结果。
在印度参与者中，视网膜血管管径与早期AMD无关。这些发现与之前在白种人和亚洲人群中进行的几项研究结果不同。
