Hentschel H, Prasa D, Bergmann I, Enden G, Plenert B, Frimlova G, Just S, Liebetrau G, Stürzebecher A, Deters M
Giftnotruf Erfurt, c/o HELIOS Klinikum Erfurt GmbH, Erfurt.
Gesundheitswesen. 2016 Jan;78(1):14-21. doi: 10.1055/s-0034-1389921. Epub 2014 Dec 19.
Because of their frequency, non-opioid analgesics (NOA) single drug exposures registered by Poisons Information Centre (PIC) Erfurt have been studied over a decade.
A retrospective analysis of frequencies, circumstances of exposure, symptom severity, and age groups in NOA single drug exposures received by the PIC Erfurt from the beginning of 2003 to the end of 2012 was undertaken.
Of all 4749 NOA single drug exposures, the 10 most frequent were caused by paracetamol (n=1 686), ibuprofen (n=1 439), acetylsalicylic acid (n=456), dipyrone (n=274), diclofenac (n=267), flupirtine (n=138), naproxen (n=41), etoricoxib (n=36), indomethacin (n=24), and dexketoprofen (n=19). Paracetamol single drug exposures increased from 158 in 2003 to 216 in 2007 and fell afterwards to 133 in 2012. Ibuprofen single drug exposures continously rose from 57 in 2003 to 258 in 2012. Adults were more often involved in NOA (53.8%) and all single drug exposures (54.1%) than children (45.9% and 45.6%, respectively). Suicidal attempts were more frequent in NOA (43.1%) than in all single drug exposures (34.2%), whereas accidental exposures or exposures in abuse were less often (33.4 and 0.2%, 46.0 and 0.9% respectively). NOA single drug exposures resulted mostly in none to minor symptoms (77.0%) and rarely in moderate (2.1%) or severe symptoms (1.0%). One adult was found dead after probable ingestion of 32 g of acetylsalicylic acid in suicidal intention.
Because many NOA are over-the-counter drugs, it is difficult to obtain data on their use. PIC data could provide information on the NOA use in the population.
由于其发生频率，对爱尔福特毒物信息中心（PIC）记录的非阿片类镇痛药（NOA）单一药物暴露情况进行了长达十年的研究。
对爱尔福特毒物信息中心在2003年初至2012年末期间收到的NOA单一药物暴露的频率、暴露情况、症状严重程度和年龄组进行回顾性分析。
在所有4749例NOA单一药物暴露中，最常见的10种药物所致暴露分别为：对乙酰氨基酚（n = 1686）、布洛芬（n = 1439）、乙酰水杨酸（n = 456）、安乃近（n = 274）、双氯芬酸（n = 267）、氟吡汀（n = 138）、萘普生（n = 41）、依托考昔（n = 36）、吲哚美辛（n = 24）和右酮洛芬（n = 19）。对乙酰氨基酚单一药物暴露从2003年的158例增加到2007年的216例，之后在2012年降至133例。布洛芬单一药物暴露从2003年的57例持续上升至2012年的258例。NOA单一药物暴露中成年人的参与率（53.8%）高于儿童（45.9%），在所有单一药物暴露中成年人的参与率（54.1%）也高于儿童（45.6%）。NOA单一药物暴露中的自杀未遂情况（43.1%）比所有单一药物暴露中的自杀未遂情况（34.2%）更频繁，而意外暴露或滥用暴露情况在NOA单一药物暴露中较少（分别为33.4%和0.2%），在所有单一药物暴露中相对较多（分别为46.0%和0.9%）。NOA单一药物暴露大多导致无至轻微症状（77.0%），很少导致中度症状（2.1%）或重度症状（1.0%）。一名成年人在有自杀意图地摄入32克乙酰水杨酸后死亡。
由于许多NOA为非处方药，很难获取其使用数据。PIC数据可提供人群中NOA使用情况的信息。
