胸部壁层和肋骨照射以及接受射波刀立体定向体部放射治疗的早期肺癌患者的毒性反应
Chest wall and rib irradiation and toxicities of early-stage lung cancer patients treated with CyberKnife stereotactic body radiotherapy.
作者信息
Podder Tarun, Biswas Tithi, Yao Min, Zhang Yuxia, Kim Ellen, Ellis Rodney J, Lo Simon S, Machtay Mitchell
机构信息
Department of Radiation Oncology, University Hospitals Seidman Cancer Center, Case Western Reserve University, 11100 Euclid Avenue, LTR B181, Cleveland, OH 44106, USA.
出版信息
Future Oncol. 2014 Dec;10(15):2311-7. doi: 10.2217/fon.14.158.
AIM
The aim of the study is to evaluate the chest wall and rib toxicities in primary lung cancer patients treated with CyberKnife-based stereotactic body radiotherapy.
MATERIALS & METHODS: In this study, data were collected from the 118 patients, of which 25 patients who had longer follow-up (mean: 21.9 months) were considered. Studied parameters were maximum point dose, doses to 1-100 cm(3) of chest wall and 1-10 cm(3) of ribs.
RESULTS
Three patients developed chest wall pain (grade I). 25 studied patients, on average, received 27.7 Gy to 30 cm(3) of chest wall and 50.4 Gy to 1 cm(3) of rib. Nine patients had more than 30 Gy dose to 30 cm(3) of chest wall. No rib bone fracture was found.
CONCLUSION
No correlations of chest wall pain and volume of irradiation were found.
目的
本研究旨在评估接受基于射波刀的立体定向体部放射治疗的原发性肺癌患者的胸壁和肋骨毒性。
材料与方法
在本研究中，收集了118例患者的数据，其中25例随访时间较长（平均：21.9个月）的患者被纳入研究。研究参数包括最大点剂量、胸壁1 - 100 cm³和肋骨1 - 10 cm³的剂量。
结果
3例患者出现胸壁疼痛（I级）。25例研究患者胸壁30 cm³平均接受27.7 Gy照射，肋骨1 cm³平均接受50.4 Gy照射。9例患者胸壁30 cm³接受的剂量超过30 Gy。未发现肋骨骨折。
结论
未发现胸壁疼痛与照射体积之间存在相关性。
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